INTRODUCTION: Hypothyroidism is six times more common in women, affecting up to 40 in 10,000 each year (compared with 6/10,000 men). METHODS AND OUTCOMES: We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of treatments for clinical (overt) hypothyroidism? What are the effects of treatments for subclinical hypothyroidism? We searched: Med...

A 71-year-old woman presented with ST segment elevation myocardial infarction (STEMI) associated with hypotension (100/70 mm Hg) and dizziness. Her husband stated that she appeared confused and was experiencing visual hallucinations. Her medical history was significant for hypertension, pulmonary embolism, hypothyroidism, and gastroesophageal reflux disease. Preadmission medications were report...

Introduction Recent prescribing policies in England and Wales have imposed significant restrictions on liothyronine general practice driven by the prohibitive costs uncertain benefits of management hypothyroidism. However, impact these usage is still unclear. Methods Data were downloaded from NHS monthly General Practice Prescribing Comparative Analysis System for Audit (CASPA) 2011–2020. Trend...

Current guidelines recommend that hypothyroid patients should be treated with levothyroxine, which in the vast majority of the cases leads to resolution of the symptoms and normalization of serum free T4 (FT4), T3 and TSH levels. However, a small group of hypothyroid patients remain symptomatic for neurocognitive dysfunction despite normal serum FT4 and TSH, which could be explained by localize...

The serum alpha-I acid glycoprotein of 9 euthyroid subjects, 14 hypothyroz"d patients and 21 hyperthyroz"d patients was determined by radial immunodiffussion in agar plates. The serum alpha1 acid glycoprotez"n level in both the hypothyroz"d and hyperthyroz"d patients were sz"gnifz"cantly lowered when compared to the euthyroid subjects. There was no sz"gnifz"cant correlation between the alpha-I ...