Objective(s): Curcumin, a plant alkaloid from Curcuma longa, possess antioxidant and anti-inflammatory properties. Recently, the antidepressant activities of curcumin were reported. Nevertheless, bioavailability of curcumin limits its therapeutic utility. Nanotechnology is a developing field that potentially enhances bioavailability and the plasma concentration of curcumin. This study investiga...

Background and Aim: In this study, we investigated the effect of immobilization stress during pregnancy on the spatial memory, anxiety-like behavior and brain BDNF level in F1 generation male NMRI mice. Materials and Methods: Twenty female pregnant mice were randomly divided into stress and control groups. The stress group received stress using a restraint cylinder (6 cm ID, 20 cm L) 60 min/da...

Introduction: Based on the documents in traditional medicine regarding the therapeutic effect of Sour orange flowers (Citrus aurantium L.) on the nervous system disorders, this experimental study was conducted to evaluate the pretreatment of Sour orange flowers extract in preventing or reducing depressive-like behaviors induced by systemic injection of lipopolysaccharide (LPS) in rats. Method: ...