Tyrosinase is the key enzyme involved in the human pigmentation process, as well as the undesired browning of fruits and vegetables. Compounds inhibiting tyrosinase catalytic activity are an important class of cosmetic and dermatological agents which show high potential as depigmentation agents used for skin lightening. The multi-step protocol employed for the identification of novel tyrosinase...

the cuckoo search algorithm is a recently developedmeta-heuristic optimization algorithm, which is suitable forsolving optimization problems. to enhance the accuracy andconvergence rate of this algorithm, an improved cuckoo searchalgorithm is proposed in this paper. normally, the parametersof the cuckoo search are kept constant. this may lead todecreasing the efficiency of the algorithm. to cop...

the mathematical modeling of fracture networks is critical for the exploration and development ofnatural resources. fractures can help the production of petroleum, water, and geothermal energy. theyalso greatly influence the drainage and production of methane gas from coal beds. orientation andspatial distribution of fractures in rocks are important factors in controlling fluid flow. the object...

the concept of intelligently controlling the search process of gravitational search algorithm (gsa) is introduced to develop a novel data mining technique. the proposed method is called fuzzy gsa miner (fgsa-miner). at first a fuzzy controller is designed for adaptively controlling the gravitational coefficient and the number of effective objects, as two important parameters which play major ro...

one of methods of improvement of the material flow is cross docking that in is considered as a good method to reduce inventory and improve customer satisfaction. too, the vehicle routing problem is one of the important problems in distribution management and its goal is to find paths for delivering various cargos. therefore, this study was conducted in order to vehicle routing problem with cros...

augmented downhill simplex method (adsm) is introduced here, that is a heuristic combination of downhill simplex method (dsm) with random search algorithm. in fact, dsm is an interpretable nonlinear local optimization method. however, it is a local exploitation algorithm; so, it can be trapped in a local minimum. in contrast, random search is a global exploration, but less efficient. here, rand...

The cuckoo search algorithm is a recently developedmeta-heuristic optimization algorithm, which is suitable forsolving optimization problems. To enhance the accuracy andconvergence rate of this algorithm, an improved cuckoo searchalgorithm is proposed in this paper. Normally, the parametersof the cuckoo search are kept constant. This may lead todecreasing the efficiency of the algorithm. To cop...

task assignment problem (tap) involves assigning a number of tasks to a number of processors in distributed computing systems and its objective is to minimize the sum of the total execution and communication costs, subject to all of the resource constraints. tap is a combinatorial optimization problem and np-complete. this paper proposes a hybrid meta-heuristic algorithm for solving tap in a h...

response surface methodology is a common tool in optimizing processes. it mainly concerns situations when there is only one response of interest. however, many designed experiments often involve simultaneous optimization of several quality characteristics. this is called a multiresponse surface optimization problem. a common approach in dealing with these problems is to apply desirability funct...