Adenosquamous lung tumours, which are extremely poor prognosis, may result from cellular plasticity. Here, we demonstrate lineage switching of KRAS+ lung adenocarcinomas (ADC) to squamous cell carcinoma (SCC) through deletion of Lkb1 (Stk11) in autochthonous and transplant models. Chromatin analysis reveals loss of H3K27me3 and gain of H3K27ac and H3K4me3 at squamous lineage genes, including So...

The use of sediments as supplementary cementitious material is increasing, but very limited information on their effect durability are available. aim this study to evaluate the and transport properties self-consolidating concrete (SCC) incorporating treated marine (TMS) dredged from Dunkirk harbor. Three SCC mixtures made with 0% (SCC-R), 10% (SCC-1), 20% (SCC-2) partial substitution cement wei...

Our objective was to study the relationships between colostral somatic cell counts (SCC, a criterion for mastitis severity at parturition) and early calf growth, blood indicators of immunity, and pre-weaning faecal and health states. Sixty-nine Holstein cows were assigned to three groups of greater (n = 21, 5051 × 10(3)), medium (n = 38, 2138 × 10(3)) and lower (n = 10, 960 × 10(3)) colostral S...

Our previous studies demonstrated various abnormalities in spermatogenesis after spinal cord injury (SCI) in cord-transected rats. In this study, we examined whether abnormalities in spermatogenesis in SCI rats were related to the degree of SCI. We used spinal cord-contused (SCC) rats as a model. Adult male Sprague-Dawley rats were subjected to various degrees of cord contusion caused by the we...

A variety of pathologic variants of cutaneous squamous cell carcinoma (SCC) has been reported, and the signet-ring variant of cutaneous SCC is extremely uncommon. We reported an 83-year-old man with signet-ring SCC arising on the back of the finger. As far as we know, only 4 cases have been described in detail, and one dermatopathologic report focused on the presence of signet-ring cells briefl...

Recent fMRI studies linked subgenual cingulate cortex (SCC) activity with feelings of guilt for acting counter to social values and altruistic donations towards societal causes. We hypothesized that SCC activity across those different tasks was driven by feelings of attachment. In order to investigate this further, we used fMRI to probe the association of empathic concern and strength of SCC ac...

The compaction of concrete is carried out with a vibrating device or using an awl. One solution in facing problems to use the Self Compacting Concrete (SCC) method also called self-flowing concrete. This study aims obtain mixture formula / composition laboratory-scale SCC-making materials that meet SCC acceptance criteria. mixing by trial and error referring values Flowability, Workability, Pas...

This study presents the experimental results about effects of Polyvinyl-alcohol (PVA) and Polypropylene (PP) fibers on fresh mechanical properties including compressive, splitting tensile strength, modulus rupture (MOR) as well toughness hybrid fiber reinforced self-compacting concrete (SCC). PVA PP were added into SCC mixtures having only macro steel also binary hybridization both micro fiber....

Stress corrosion cracking (SCC) in light water reactors (LWRs) has been a persistent form of degradation in the nuclear industry. Examples of SCC can be found for a range of materials in boiling and pressurized water reactor environments, including carbon steels, stainless steels, and nickel-base alloys. The evolution of SCC is often characterized by a long initiation stage followed by a phase ...