background: wearing spectacles is the most common approach in correcting the refractive errors worldwide. due to harmful effects of overexposure to solar ultraviolet radiations, the usage of multi-layer coatings in ophthalmic lenses has recently been increased. these lenses can reduce the reflections and hence increase the transmission of visible light; they can also decrease the transmission o...

objective: zirconia cores have limited light transmittance and data are scarce on light transmission through zirconia cores with and without the veneering ceramic.   methods: in this in vitro study, disc-shaped specimens (11.5 mm in diameter and 0.4 (0.05) mm in thickness) were fabricated of three types of zirconia namely mamut, heany and zirkonzahn (n=5). a disc-shaped specimen (11.5 mm in dia...

Glyceryl trinitrate is a weak inhibitor of platelet aggregation in vitro. Its effect on platelet aggregation in response to U46619 (a thromboxane/endoperoxide receptor agonist) was studied turbidometrically in platelet-rich plasma from healthy volunteers. The object was to determine whether inhibition was influenced by a period of preincubation between preparation of platelet-rich plasma and ad...

To study the resistance to standard dosage of clopidogrel among Iranian patients following percutaneous coronary intervention measured by platelet aggregation test. Patients undergoing percutaneous coronary intervention in Imam Hussein Medical center, Tehran, Iran, who were under treatment with aspirin, but had no history of clopidogrel usage, entered the study. Patients received standard dosag...

We describe here a 12-channel aggregometer, evolved from the instrument described by Beug & Gerisch in 1972, which records the course of aggregation or agglutination of cells or other particles by following the changes in light-scattering of the aggregating suspension. The instrument incorporates a simple memory system for condensing the data, introduces an improved cuvette design, and can be a...

Low-dose aspirin (ASA) is the most common anti-platelet therapy provided to patients with atherosclerotic disease such as peripheral arterial (PAD) and carotid artery stenosis (CAS). However, between 25% 30% of are nonsensitive their therefore at a four-fold higher risk adverse cardiovascular events. In this study, we investigated if Platelet Works, point-of-care platelet function test, could d...

Platelets play a critical role in the pathophysiology of atherothrombotic disease. A pivotal event contributing to the understanding of platelet-dependent clot formation was the development of the platelet aggregometer in 1962.1 An aggregometer specifically measures the ability of platelets to adhere via glycoprotein IIb/IIIa (integrin IIb 3), and thousands of articles using this technique have...

The aim of current study was evaluating the frequency of clopidogrel resistance and its impact on clinical outcome of patients in Iranian patients. Patients undergoing percutaneous coronary intervention in Imam Hussein Medical center, Tehran, Iran, who received standard dosage of clopidogrel (Plavix®, Sanofi, France, 600 mg loading dose and 75 mg/day afterward) were recruited. Platelet aggregat...

The aim of current study was evaluating the frequency of clopidogrel resistance and its impact on clinical outcome of patients in Iranian patients. Patients undergoing percutaneous coronary intervention in Imam Hussein Medical center, Tehran, Iran, who received standard dosage of clopidogrel (Plavix®, Sanofi, France, 600 mg loading dose and 75 mg/day afterward) were recruited. Platelet aggregat...