suppressor influences lifespan in flies highlight the complexities inherent in modulating the activity of this potent and versatile transcriptional regulator. Promoting efficient regeneration while preventing cancer is critical for tissue homeostasis. Genes and processes that influence the balance between regenera-tion and cancer are thus likely to affect lifespan of metazoans. Supporting this ...

The yeast Saccharomyces cerevisiae is a model organism for replicative aging studies; however, conventional lifespan measurement platforms have several limitations. Here, we present a microfluidics platform that facilitates simultaneous lifespan and gene expression measurements of aging yeast cells. Our multiplexed high-throughput platform offers the capability to perform independent lifespan e...

Recently, we administered fish oil containing eicosapentaenoic acid and docosahexaenoic acid (DHA) to senescence-accelerated mice P8 (SAMP8), in order to investigate the effects on lifespan. Surprisingly, the lifespan of SAMP8 that were fed fish oil was shortened significantly, through a mechanism that likely involved lipid peroxidation. In this study, we investigated this phenomenon in further...