Latest estimates indicate that nutritional deficiencies account for 3 million child deaths each year in less-developed countries. Targeted nutritional interventions could therefore save millions of lives. However, such interventions require careful optimization to maximize benefit and avoid harm. Progress toward designing effective life-saving interventions is currently hampered by some serious...

Ubiquitin-fold modifier 1 (UFM1) is one of the newly-identified ubiquitin-like proteins. Similar to ubiquitin, UFM1 is conjugated to its target proteins by a three-step enzymatic reaction. The UFM1-activating enzyme, ubiquitin-like modifier-activating enzyme 5 (UBA5), serves as the E1 to activate UFM1; UFM1-conjugating enzyme 1 (UFC1) acts as the E2 to transfer the activated UFM1 to the active ...

introduction: although the effectiveness of paroxetine and attention modification program has been studied separately in treating social anxiety disorder, there has been no research comparing them according to the literature. the aim of this study was to compare the effectiveness of paroxetine, attention modification program (amp) and combination of both on improving the social anxiety symptoms...

BACKGROUND Tuberculosis (TB) and under-nutrition are widespread in many low and middle-income countries. Momentum to prioritize under-nutrition has been growing at an international level, as demonstrated by the "Scaling Up Nutrition" movement. Low body mass index is an important risk factor for developing TB disease. The objective of this study was to project future trends in TB related outcome...

In investigating whether an intervention has an effect on survival, we exploit the flexibility of weighted logrank tests for constructing optimal tests sensitive to specified patterns of changes in the ratios or differences of the hazards as a function of time. The tests presented seem appropriate if either the intervention on trial imposes changes in life style, such as a diet modification or ...