OBJECTIVE Local anesthetic solutions with vasoconstrictors are not contraindicated in hypertensive patients, but due to their hemodynamic effects, local anesthetics without vasoconstrictors are mainly preferred by the clinicians. The aim of this study was to compare hemodynamic effects of three different local anesthetics without vasoconstrictors during tooth extraction in hypertensive patients...

Lidocaine HCl injection is a sterile product that easily contaminated when opened. The temperature and humidity in the storage conditions also affect quality of drug viewed from UV-Vis spectrophotometric absorption value. aimed this study to find out how effect on profile 2% lydocaine by spectrophotometry. used 27 ampoules lidocaine was qualitatively analyzed using lasted for 14 days first stor...

We explored the potential for EXPAREL to interact with lidocaine. Sixty (60) male Yucatan Swine were randomized into 20 groups (N = 3/group). EXPAREL (2 or 4 mg/kg) and/or lidocaine HCl solution 1% or 2% (with epinephrine 1 : 200,000) were injected subcutaneously along a 5 cm virtual incision line. The effects on the pharmacokinetics of bupivacaine and lidocaine were examined when 5, 10, 20, an...

PURPOSE Low-frequency ultrasound has a significant effect on the transdermal permeation of high molecular weight drugs. However, the rate of permeation in pulsed mode is quite low necessitating considerable time to apply the ultrasound. 0.5 MHz ultrasound, which is a relatively higher frequency in the low-frequency range, can be applied in high intensity in continuous mode. METHODS A transduc...

Dosage for the galvanic stimulation for iontophoresis varies. Clinicians manipulate the duration or the amplitude of the current, but it is not known which is more effective. We compared the anesthetic effect of lidocaine HCL (2%) by manipulating the current parameters on 21 healthy volunteers (age: 21.2 ± 4.2, height 170.7 ± 10.2 cm, mass 82.1 ± 19.2 kg). Three conditions were administered in ...

APRIL 2010 I RETINA TODAY I 59 I ntravitreal injection has become one of the most commonly performed vitreoretinal procedures, but there is little agreement in the retina community regarding what type of topical anesthetic is most effective for it. We performed a study to assess the effectiveness of gel vs liquid topical anesthetics for this application.1 This prospective, single-center study i...

OBJECTIVE To evaluate at which pH level various local anesthetics precipitate, and to confirm which combination of corticosteroid and local anesthetic crystallizes. METHODS Each of ropivacaine-HCl, bupivacaine-HCl, and lidocaine-HCl was mixed with 4 different concentrations of NaOH solutions. Also, each of the three local anesthetics was mixed with the same volume of 3 corticosteroid solution...

PURPOSE Three identical single-dose, randomized, double-blind, parallel-group, active-controlled multicenter studies were conducted to compare the safety and efficacy of articaine HCl (4% with epinephrine 1:100,000) to that of lidocaine HCl (2% with epinephrine 1:100,000) in patients aged 4 years to 79 years, with subgroup analysis on subjects 4 to < 13 years. METHODS Fifty subjects under the...

abstract statement of problem: the ph of the human abscess has been measured as low as 5.0. this low ph could potentially inhibit setting reactions, affect adhesion, or increase the solubility of root end filling materials hence affect the compressive strength. moreover, root end filling materials might expose or even mix with lidocaine hcl during periapical surgery. objectives: the aim of this...

Objective: Propofol is the most frequently used agent for intravenous anesthesia administration. However, during propofol injection, pain may develop in hand and forearm region cause unwanted situations. Different applications have been to prevent injection pain. Although lidocaine often proprofol pain, anesthetic ketamine, which has an analgesic feature, also preferred. In recent years, featur...