Peptide amphiphiles (PAs) are promising tools for the intracellular delivery of numerous drugs. PAs are known to be biodegradable systems. Here, four PA derivatives containing arginine and lysine conjugated with fatty acyl groups with different chain lengths, namely, PA1: R-K(C14)-R, PA2: R-K(C16)-R, PA3: K(C14)-R-K(C14), and PA4: K(C16)-R-K(C16), where C16 = palmitic acid and C14 = myristic ac...

We propose two novel extensions to the Match-LSTM Boundary model for question answering on the SQuAD dataset. First we propose doing attention in the passage and question encoders. Second we propose adding a one-way conditional dependency between start-of-span and end-of-span prediction. In our evaluations, we show that these extensions result in a model that outperforms our implementation of v...

In this study, matrix-type transdermal patches containing diclofenac diethylamine were prepared using different ratios of polyvinylpyrrolidone (PVP) and ethylcellulose (EC) by solvent evaporation technique. The drug matrix film of PVP and EC was casted on a polyvinylalcohol backing membrane. All the prepared formulations were subjected to physical studies (moisture content, moisture uptake, and...

Pantoea ananatis is an emerging phytopathogen that infects a broad spectrum of plant hosts. Here, we present the genomes of two South African isolates, P. ananatis PA4, which causes center rot of onion, and BD442, isolated from brown stalk rot of maize.

The direct flight muscles of Drosophila melanogaster are innervated by the anterior dorsal mesothoracic (ADM) nerve and the mesothoracic accessory (MAC) nerve. Each of the four conspicuously large axons in the ADM nerve serves one of the muscles designated/>aV,/><24 andpa5. Muscle pa4 is additionally innervated by a very small neurosecretory axon. Muscle pa6, also innervated by the ADM ne...

A new compound with a peroxisomicine (dimeric hydroxyanthracenone type) structure was isolated from Karwinskia parvifolia and denominated peroxisomicine A4 (PA4). The stereochemistry of the stereogenic centers of this compound and the previously isolated peroxisomicine A3 (PA3, 3) was elucidated using CD, 13 C NMR and 1 H NMR spectra. Four peroxisomicine stereoisomers were cytotoxic to Chang an...

Abstract Fruit leather is a product made from processed fruit shaped like thin sheet. This study aimed to determine the panelist’s preference for produced combination of pedada and api-api fruit. The used Completely Randomized Design (CRD) with five treatments three repetitions. treatment formula PA1 (Pedada 90%: Api-api 10%), PA2 80%: 20%), PA3 70%: 30%), PA4 60%: 40%) PA5 50%: 50%). results s...