The efficacy of ascorbic acid therapy in Chediak-Higashi syndrome (CHS) was assessed in two humans and in the mouse model of this disease. Ascorbic acid (6 g/day) was given for 8 mo to two brothers (26 and 27 yr old) with CHS. The therapy had no effect on the clinical course of these patients and no change in their complete blood count or abnormal leukocyte morphology (giant lysosomes). In addi...

BACKGROUND In renal transplantation patients, therapeutic drug monitoring of the calcineurin (CN) inhibitor cyclosporin A (CsA) is mandatory because of the drug's narrow therapeutic index. Pharmacodynamic monitoring of CN inhibition therapy could provide a tool to define and maintain the therapeutic efficacy of CsA therapy. We investigated the effect of variation in cell counts of leukocyte sub...

Platelets are key players in haemostasis and represent a pivotal link between inflammation, immunity and atherogenesis. Depending on the (patho)physiological environment platelets modulate various leukocyte functions via release of inflammatory mediators and direct cell-cell interactions. Elevated levels of circulating platelet-leukocyte aggregates are found in patients suffering from several t...

Type 2 DM is a complex chronic multifactorial disease involving many organs. Insulin resistance in type patients that occurs due to insulin deficiency or defects can also occur metabolic syndrome. This study aims determine the profile of with based on characteristics HbA1c levels, leukocyte and hypertension status at Citra Husada Jember Hospital 2022. used descriptive method case series design....

Aim: to evaluate the dynamics of leukocyte inflammatory markers in patients with ST-elevation myocardial infarction (STEMI) after percutaneous coronary intervention (PCI) depending on ejection fraction left ventricular (LV). Material and methods. The study group consisted 23 consecutive STEMI admitted Regional Clinical Cardiology Center Chernivtsi, who underwent successful reperfusion treatment...

Allograft rejection is a significant cause of renal transplant failure which needs prompt diagnosis and treatment for graft salvage. Angiotensin II type 1 receptor antibody-mediated (AT1R-AMR) increasingly being identified as the etiology in kidney recipients with allograft but without detectable human leukocyte antigen (HLA) antibodies. While some reports have suggested that AT1R-AMR may be re...

Background: Recurrent spontaneous abortion (RSA) is defined as three or more se-quential abortions before the twentieth week of gestation. There are evidences to sup-port an allo-immunologic mechanism for RSA. One of the methods for treatment of RSA is leukocyte therapy; however there is still controversy about effectiveness of this method. Objectives: To evaluate the effectiveness of leukocyte...

Aim . To reveal the significance of major histocompatibility complex and human leukocyte antigen evolutionary divergence in transplantation allogeneic hematopoietic stem cells. The article traces evolution discusses reasons for its formation on example recognition system invertebrates, plants, jawed vertebrates humans. concepts immunopeptidome have been defined; data their impact therapy outcom...