objective: hla-g is a nonclassical major histocompatibility complex antigen and is expressed as seven isoforms, including four membrane bound (hla-g1 to –g4) and three soluble (hla-g5 to –g7) forms. the pattern of selective expression of hla-g transcripts in tissues shows the existence of a tight transcriptional control on the gene expression. it has been revealed that cytokines including inter...

background: pediatric bronchial asthma is associated with considerable morbidity. the study was carried out to examine the association of human leukocyte antigen (hla)- class ii with the disease as we found no similar study on asian indian population. objective: to define the hla-class ii antigens in asian indian pediatric patients with asthma. methods: a total of 103 children with asthma and 1...

results of all participants, 104 patients (52%) were diagnosed with cmv infection. there was no significant difference between the two groups, with and without cmv infection, in terms of patient’s characteristics. the cmv infection, in patients receiving a transplanted organ from deceased donor, was significantly more prevalent than in those receiving kidney transplant from living donor (63% vs...

the object of this cross sectional study was to determine the hcv subtype 3a envelope protein binding affinity with human leukocyte antigen. envelope 1 (e1) protein is one of the structural proteins responsible for entering the cells through the receptors. the binding affinity of e1 protein epitopes to the selected human leukocyte antigen (hla) class i alleles was investigated using the compute...

OBJECTIVES Although previous studies have investigated the effect of human leukocyte antigen matching on long-term outcomes after heart transplants, its role in the prognosis after a heart transplant remains unclear, particularly with respect to short-term survival. MATERIALS AND METHODS We evaluated the human leukocyte antigen mismatch on in-hospital mortality of 158 consecutive patients who...

OBJECTIVES We sought to discover which types of injuries were related to human leukocyte antigen DR expression in acute rejection and late chronic injury in renal allografts. MATERIALS AND METHODS Ninety-two recipients were separated into the early acute rejection group, the late monocyte infiltration group, and the late chronic injury group. Ten subjects with acute cellular rejection receive...

To simplify the construction of monoclonal antibody (MAb) libraries to complex biological systems, the use of a cascade procedure has been investigated. The procedure continually restricts MAb production to those antigens previously so unidentified. Murine macrophage membranes were detergent-solubilized and purified by Lens culinaris lectin affinity chromatography. Prior to immunization of rats...

Background: During pregnancy, the maternal immune system is in close contact with cells and tissue from the semiallogenic fetus .The Human Leucocyte Antigen (HLA) class Ib molecules, HLA-E, -F and -G, are expressed at the materno-fetal interface. Because of the apparent immunoregulatory functions of these proteins, they may be involved in successful acceptance of the semi-allogenic fetus during...

the major histocompatibility complex (mhc) genes are the most polymorphic loci in the human genome and have been widely studied in various populations and ethnic groups. investigations into the hla genes and proteins have been useful tool for anthropological, transplantation and disease association studies. the polymorphism of the hla class i (a, b, c) and class ii (drb1, dqa1, dqb1) genes were...