background: acromegaly is associated with increased morbidity and mortality related to cardiovascular diseases. leptin (lep) and leptin receptor (lepr) gene polymorphisms can increase cardiovascular risks. the aim of this study was to investigate association between the frequencies of lep and lepr gene polymorphisms and subclinical atherosclerosis in acromegalic patients. methods: forty-four ac...

Leptin, an adipocyte-derived cytokine (adipokine), has plethora of physiological roles in the body, particularly onset puberty, reproduction and immune function animal. Leptin binds with leptin receptor (LEPR) activates different intracellular signaling pathways to activate downstream gene expression process execute its functions. The present mini-review focuses on our current understanding abo...

The use of polymorphic markers in breeding programmes could make selection more accurate and efficient. A total of 324 individuals from six Iranian cattle populations (Sarabi, Golpayegani, Sistani, Taleshi, Mazandarani, Dashtiyari), F1 Golpayegani × Brown Swiss and Iranian buffalo populations were genotypedfor the Pit-1 HinfI and leptin Sau3AI polymorphisms by the polymerase chain reactio...

background leptin and adiponectin are two hormones, which are released from adipocytes in order to control energy expenditure. both hormones are also involved in glucose homeostasis through control of insulin secretion from pancreatic islets. since pdx1, pparγ, and foxm1 play important roles in islets function, it is essential to understand how these genes are regulated in the islets of langerh...

background: leptin is a protein product of obesity gene and is synthesized mainly by adipose tissue. objective: the aim of this study was to determine maternal and neonatal serum leptin levels in term preeclamptic and normal pregnancies. materials and methods: this cross sectional study was performed on 37 preeclamptic and 40 normotensive term pregnant women without other disease. serum level o...

background: leptin and adiponectin are the two key metabolic hormones secreted from adipocytes to control food intake and energy expenditure. the action of both hormones in regulation of gonadotropin releasing hormone (gnrh) secretion from the hypothalamus is mediated through kisspeptins. kisspeptins are products of kiss-1 gene. leptin and adiponectin are modulators of kiss-1 expression in the ...

objective(s):the aim of the study was to investigate the relationship between insulin resistance (ir) and leptin (lep) gene polymorphisms in peritoneal dialysis (pd) patients. materials and methods: from july 1, 2011 to august 1, 2011, patients who received chronic pd were chosen and divided into three groups (dm, high homr-ir, and low homr-ir). two pcr products of lep were sequenced and aligne...

Leptin is a hormone which functions in the regulation of energy homeostasis via suppression appetite. In zebrafish, there are two paralogous genes encoding leptin, called lepa and lepb . gene expression study, we found that gene, not , was significantly downregulated under state insulin-resistance zebrafish larvae, suggesting plays role glucose homeostasis. current characterised -deficient ( −/...

identification of genes affecting energy balance, milk yield and feed intake is an interesting area of researches in animal breeding. leptin gene polymorphism is associated with key economic affair. considering rich resources for animals, in our country, accomplishing a few assays to identify a gene that controls her traits with molecular genetics, and identifying the candidate genes in sheep b...