Hypertrophic cardiomyopathy is known as Leopard syndrome, which is a mnemonic rule for multiple lentigines (L), electrocardiographic conduction abnormalities (E), ocular hypertelorism (O), pulmonary stenosis (P), abnormalities of genitalia (A), retardation of growth (R), and deafness (D). We report the case of a 12-year-old patient with some of the abovementioned characteristics: hypertelorism,...

Cutaneous signs may be the first indications of an internal disease. Any definitive sign of a neoplastic disease is of special importance since early diagnosis and early treatment may make a telling difference in improving prognosis. Presented is a 68-year-old patient with advanced stage melanoma that was associated with the appearance of multiple acral lentigines. The exact time-course of onse...

The coexistence of neurofibromatosis with partial unilateral lentigines raises the possibility that partial unilateral lentigines could be a variant or forme fruste of segmental neurofibromatosis. Our patient had no cutaneous lesions of neurofibromatosis but had bilateral Lisch nodules in the eyes. Since Lisch nodules are characteristic of neurofibromatosis, we conclude that the partial unilate...

Atypical Lentigines in aManWithMixedAfrican American andWhite Race/Ethnicity Receiving Long-termVoriconazole Therapy Voriconazole, an antifungal agent frequently used in systemic fungal infections, has been implicated in phototoxicity and photoaging.1 Chronic voriconazole phototoxicity and accelerated photoaging may contribute to the development of melanoma and squamous cell carcinoma.1,2 We de...

Solar lentigines are benign lesions usually found on sun-damaged skin. We investigated twelve cases of solar lentigines through dermoscopy and reflectance confocal microscopy, performed before, and 30 min and 10 days after, a single treatment with a Q-switched ruby laser. At baseline, all lesions showed characteristic features of solar lentigines in reflectance confocal microscopy analysis: reg...

Five familial cases exhibited ephelides-like multiple lentigines, and we examined three of them, a mother and two sons. All three patients presented with small dark-brown maculae on the face and neck and electrocardiographic abnormalities. These findings sufficed to fulfill the criteria for LEOPARD syndrome (multiple lentigines syndrome), although they lacked five of seven major clinical featur...

BACKGROUND AND OBJECTIVES Solar lentigines are commonly found in sun-exposed areas of the body including hands, neck, or face. This study evaluates the efficacy of an intense pulsed light (IPL) device, with wavelengths between 500 and 635 nm and delivered with a targeted tip, for the treatment of solar lentigines on Japanese skin. STUDY DESIGN/MATERIALS AND METHODS Forty Japanese patients wit...

Background: Although cryotherapy is still the first-line therapy for solar lentigines, due to side effects such as post-inflammatory hyperpigmentation (PIH), especially in patients with darker skin types, pigment specific lasers should be considered as initial treatment. The aim of this study was to evaluate the efficacy and safety of cryotherapy in comparison with 595-nm pulsed dye laser (PDL)...

BACKGROUND Very little is known about possible association of nevi and melasma. The study objective was to determine if there is an association between melasma and existence of different kinds of nevi. METHODS In a case-control study, 120 female melasma patients referred to dermatology clinic of Ardabil and 120 patients referred to other specialty clinics who lacked melasma were enrolled afte...

Varón de 11 años de raza caucásica y fototipo II con dermatitis atópica, que presenta desde hace 2 meses múltiples lesiones maculosas hiperpigmentadas de 1-2 mm de diámetro en huecos antecubitales (fig. 1). La dermatoscopia muestra retículo pigmentado delicado y zonas con glóbulos marrones (fig. 2). Durante los 8 meses previos a la consulta el paciente aplicó, sin realizar fotoprotección solar,...