Canine leishmaniosis (CanL) is caused by the parasite Leishmania infantum and is a systemic disease, which can present with variable clinical signs, and clinicopathological abnormalities. Clinical manifestations can range from subclinical infection to very severe systemic disease. Leishmaniosis is categorized as a neglected tropical disease and the complex immune responses associated with Leish...

BACKGROUND The objective of this study was to evaluate and compare the evolution of the profile currently recommended by the International Renal Interest Society (IRIS) (sCr, UPC and sSDMA) with a panel of other different kidney biomarkers during treatment for canine leishmaniosis. This panel included three urinary glomerular biomarkers (uIgG, uCRP and uferritin) and three urinary tubular bioma...

The Effect of BASNEF Model-Based Education on Preventive Behavior Leishmaniosis in High School Students

due to the high prevalence of anthroponotic cutaneous leishmaniosis (acl) in barn city, a survey was carried out to determine epidemiological characteristics of acl in barn in 1992. for this purpose, 23 out of the total 51 schools (elementary, junior high and senior high) were randomly selected and 6053 students were examined. the prevalence of acute sores and scars were 2% and 17% respectively...

in a sand-fly survey, conducted for two years (1992-93) in ghirkarzjn, fars province a total of 1020 female phlebotomus keshishiani were dissected, of which 12 females were found to have promastigotes. promastigotes of six pb. keshishiani were inoculated to six hamsters and one hamster became infected, amastigotes were observed in the spleen, but the culture of parasite was not possible due to ...

Canine leishmaniosis is a widely spread zoonosis that is potentially fatal to humans and dogs. Infection with Leishmania infantum is considerably more prevalent than clinical disease, and infected dogs with no signs of disease might, potentially, transmit infection. Diagnosis of asymptomatic infection by serology is insufficient and PCR markedly increases its sensitivity. A new therapy exclusiv...

A method for the evaluation of splenic cellularity using samples collected by fine-needle aspirative biopsy was standardized in this work. The procedure includes erythrocyte lysing, preparation of cytospin films and staining by histochemical and immunocytochemical techniques. The cellular profiles of spleen preparations were compared with those observed in peripheral blood samples subjected to ...

The use of toll-like receptor agonists in immunotherapy is a new approach in the prevention of immunosuppression during fatal Leishmania parasite infection. The objective of such immunotherapy is to activate specific cell-mediated immune responses, macrophage activation and antigen-responsive inflammation, to kill intracellular amastigotes. Toll-like receptor agonist-based treatment in immunoco...

BACKGROUND Uncoupling protein 2 (UCP2) is a mitochondrial transporter that has been shown to lower the production of reactive oxygen species (ROS). Intracellular pathogens such as Leishmania upregulate UCP2 and thereby suppress ROS production in infected host tissues, allowing the multiplication of parasites within murine phagocytes. This makes host UCP2 and ROS production potential targets in ...