Benign metastatic leiomyomatosis (BML) is a rare disease characterized by smooth muscle cell proliferation in extrauterine sites including the lung, abdomen, pelvis, and retroperitoneum. Depending on location, BML is classified as intravenous leiomyomatosis and diffuse peritoneal leiomyomatosis. Pathogenesis of BML can be iatrogenic after previous myomectomy or hysterectomy, hormonal, or coelom...

BACKGROUND Intravenous leiomyomatosis (IVL) is defined as an intraluminal growth of benign smooth muscle cells in either venous or lymphatic vessels outside the confines or even in the absence of leiomyomas. Benign metastasizing uterine leiomyoma is defined as a histologically benign uterine smooth muscle tumor that acts in a somewhat malignant fashion and produces benign metastases. We report ...

I read with great interest the article by Li et al. [1]. As rightly outlined in this remarkable review of the literature, extracting data solely from case reports is associated with an inherited bias. Only three intraoperative deaths were recorded, thus yielding a mortality rate of 1.5%. The one-stage approach in which a thoraco-laparotomy is performed under cardiopulmonary bypass with or witho...

We report on an exceedingly rare case of cutaneous and uterine leiomyomatosis in a 58-year-old Caucasian woman associated with ovarian cystadenoma and complete deletion of the fumarate hydratase gene. All patients and their family members with verified mutation have to be regularly screened for associated neoplasms, in particular papillary renal cell carcinoma (HLRCC, hereditary leiomyomatosis ...

Uterine leiomyomatosis as a rare cause of tumor thrombus presenting with abnormal uterine bleeding

Introduction: Alport syndrome with diffuse pelvic leiomyomatosis is a complex combination for which the course of treatment not well described. This case describes outcomes trial gonadotropin-releasing hormone analogues as an alternative to extensive surgery. Case Report: A 47-year-old female patient, known associated leiomyomatosis, was referred our gynecological service because mass. The pati...

Leiomyomatosis peritonealis disseminata is a very rare condition characterized by the development of multiple smooth muscle-like nodules in the peritoneal cavity. It is associated with increased serum levels of gonadal steroids. The present report describes a 29-year-old patient underwent transabdominal hysterectomy and Bilateral Salpingo oophorectomy six years ago because of leiomyomatosis per...

Whereas uterine leiomyoma is a common woman disease, intravenous leiomyomatosis with intracaval and intracardiac complications is a rare condition. The initial presentation is dependent upon the severity of the intracardiac involvement, although complete surgery is the best treatment. The case of a 39-year-old woman is described here, with an initial presentation of dyspnea and right heart fail...

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