Legionnaires' disease is often associated with neurological findings. Despite such findings, computed tomography and neuropathological investigations are typically normal. This report describes a reversible lesion of the corpus callosum identified on magnetic resonance imaging (MRI) in a patient with legionnaires' disease. MRI may show previously undocumented neuropathology in acute legionnaire...

Legionnaires' disease is an important cause of community-acquired and hospital-acquired pneumonia. Although uncommon, Legionnaires' disease continues to cause disease outbreaks of public health significance. The disease is caused by any species of the Gram-negative aerobic bacteria belonging to the genus Legionella; Legionella pneumophila serogroup 1 is the causative agent of most cases in Euro...

The interaction between normal cynomolgus monkey alveolar macrophages and Legionnaires disease bacteria was studied by transmission electron microscopy. After ingestion of Legionnaires disease bacteria, the organisms replicated within macrophages and destroyed the phagocytic cell.

Almost 40 years ago, a large outbreak of pneumonia caused by a previously unidentified agent occurred at a hotel in Philadelphia (PA, USA), affecting 182 persons and causing the death of 29 [1]. All cases had attended a convention of the American Legion, a US wartime veteran service organisation. Both the causative agent of the outbreak and the disease were named after this event: Legionella sp...

OBJECTIVE To investigate the source and risk factors associated with Australia's largest outbreak of Legionnaires' disease. DESIGN AND SETTING Epidemiological and environmental investigation of cases of Legionnaires' disease associated with visits to the Melbourne Aquarium; two case-control studies to confirm the outbreak source and to investigate risk factors for infection, respectively. P...

BACKGROUND Legionnaires' disease, a severe pneumonia, is typically acquired through inhalation of aerosolized water containing Legionella bacteria. Legionella can grow in the complex water systems of buildings, including health care facilities. Effective water management programs could prevent the growth of Legionella in building water systems. METHODS Using national surveillance data, Legion...

OBJECTIVE To study the source of non-outbreak legionnaires' disease, particularly the role of cooling towers, by comparing the locations of patients' homes in relation to the location of cooling towers. DESIGN Retrospective, descriptive study of a case series of patients with legionnaires' disease ill between 1978 and 1986 and, for comparison, a case series of patients with lung cancer. A pro...

TO THE EDITOR—Legionnaires’ disease is becoming a rapidly increasing public health problem in the United States, with the number of reported cases of legionellosis more than tripling since 2000 [1, 2]. Legionellosis, including Legionnaires’ disease, is typically caused by exposure to aerosolized water contaminated with high levels of Legionella bacteria. The incubation period for Legionnaires’ ...

In January 1977, the C enter for Dis­ ease Control (CDC) of the federal gov­ ernm ent announced1,2 that its scientists had isolated a bacteria-like organism that a p p e a re d to cause th e o u tb reak o f Legionnaires’ D isease. The published scientific evidence that formed the basis of this announcem ent was limited. In ad­ dition, a preliminary report has recently been transm itted by CDC (...

In June and July 2008, two office workers were admitted to a Dublin hospital with Legionnaires' disease. Investigations showed that cooling towers in the basement car park were the most likely source of infection. However, positive results from cooling tower samples by polymerase chain reaction (PCR) did not correlate with subsequent culture results. Also, many employees reported Pontiac fever-...