We tested the hypothesis that increased hemodynamic augmentation and mechanical performance could be achieved by using a variable frequency pulse train (VFT) to stimulate the latissimus dorsi muscle (LDM), compared to the conventional constant frequency pulse train (CFT) used in cardiomyoplasty. In dogs (n = 6), a vascular delayed LDM was wrapped posteriorly around the heart. LDM was conditione...

Cooperative safety driving systems using vehicle-to-vehicle and vehicle-to infrastructure communication are developed. Sensor data of vehicles and infrastructures are communicated in the cooperative safety driving system. LDM (Local Dynamic Map) is standardized by ETSI (European Telecommunications Standards Institute) to manage the vehicle sensor data and the map data. Implementations of LDM ar...

Vascular deafferentation of the Latissimus Dorsi Muscle (LDM) for dynamic cardiomyoplasty is an important cause of ischemia in the distal portion of the muscle with degeneration of muscle fibres and consequent reduction in the effectiveness of the surgery. Experimental studies suggest that a vascular delay procedure and a 10-day delay adaptation significantly improve the distal perfusion and fu...

Improved understanding of the mechanisms of action in dynamic cardiomyoplasty (DCMP) and continued research in the stimulation of the latissimus dorsi muscle (LDM) contribute to the development of new stimulation strategies aimed at improving DCMP outcomes. Cautious initiation of LDM stimulation sooner after surgery than currently practiced may provide the patient earlier hemodynamic assistance...

Monitoring is an essential process to observe and improve the reliability and the performance of large-scale distributed multimedia (LDM) systems. Monitoring events generated by LDM systems is necessary for observing the run-time behavior of LDM systems and providing status information required for managing such applications. However, correlated events are generated concurrently and could be di...

CD30 is a 120-kDa type I transmembrane glycoprotein belonging to the tumor necrosis factor receptor superfamily. Overexpression of CD30 has been reported in Hodgkin's lymphoma (HL) and anaplastic large-cell lymphoma (ALCL). CD30-targeted treatment with antibody-drug conjugates (ADCs) can lead to promising clinical benefit. Lidamycin (LDM), consisting of an apoprotein LDP and an active enediyne ...

The composition and patterns of metabolism of phospholipids isolated as part of a lipid-depleted membrane fragment (LDM fragment) and associated with the membrane adenosine triphosphatase complex have been compared with those of the bulk membrane phospholipid. The bulk lipid was extracted from washed membranes with sodium cholate. The LDM fragments, which contained a portion of the electron tra...

BACKGROUND It is not known whether the coronary heart disease (CHD) mortality risk associated with recent (RDM; <10 years) or long-standing diabetes mellitus (LDM; > or =10 years) varies by sex. METHODS The relationship between diabetes duration and CHD mortality was evaluated among 10 871 adults (aged 35-74 years at baseline) using the 1971-1992 National Health and Nutrition Examination Surv...

Conventional chemotherapy drugs administered at a maximum tolerated dose (MTD) remains the backbone for treating most cancers. Low-dose metronomic (LDM) chemotherapy, which utilizes lower, less toxic, doses given on a close regular basis over prolonged periods, is an alternative and better tolerated potential strategy to improve chemotherapy. LDM chemotherapy has been evaluated preclinically an...

Long term dynamic cardiomyoplasty is associated with atrophy, fibrosis, and fatty infiltration of the latissimus dorsi muscle (LDM). Ischemia, decreased muscle preload and chronic electrical stimulation have been recognized as factors for muscle deterioration after cardiomyoplasty. Transposition of the LDM around the heart might be associated with damages to the thoracodorsal nerve that can con...