Interactions between platelets with injured vascular endothelium contribute to thrombotic occlusion. A murine monoclonal antibody [7E3 F(ab')2] to the platelet GPIIb/IIIa receptor complex was used to inhibit platelet aggregation in an experimental model of coronary artery thrombosis. Prevention of thrombotic occlusion by 7E3 F(ab')2 (0.8 mg/kg bolus i.v.) was studied in dogs with direct current...

We report the case of a 63-year-old man, admitted after a traffic accident. Clinical examination found chest trauma, mandibular and long bone fractures but there was no cerebral ischemic signs. The chest X-ray showed a widening of the mediastinum; therefore an aortography demonstrated a false aneurysm, an intimal flap of the left common carotid artery (LCCA) and a middle aortic arch disruption....

Background: Iron overload is caused early progression of atherosclerosis in beta thalassemia patients due to regular repeated blood transfusion. MRI T2* is a gold standard non-invasive method for detecting hepatic and cardiac iron overload. The aim of this study was the comparison of carotid intima media thickness (CIMT) in the patients and healthy control groups with Doppler ultrasound for ear...

There is an increasing awareness within the nuclear power industry of the need to perform detailed life cycle cost analyses (LCCA) to quantify the risks associated with investing in new equipment that is needed to improve plant capacity factors. In undertaking LCCA, there are three primary factors that need to be addressed: What are the considerations that go into performing life cycle cost ana...

Family data on 299 probands with spinocerebellar types, 163 with late cortical cerebellar atrophies (LCCA), and 180 with olivopontocerebellar atrophies (OPCA) were analysed. Spinocerebellar types included cases with cerebellar ataxia combined with spasticity. Their family history was not compatible with sex linked inheritance. There were few recessive cases occurring before 24 years of age. The...

Assessing the life cycle economic and environmental impacts of road pavements is critical for achieving long-term sustainability in transport systems. Life cost analysis (LCCA) assessment (LCA) methods have been widely applied to pavements, however, there still a need identify which approaches boost both benefits, simultaneously. This study develops an integrated LCCA-LCA method, identifies mer...

PURPOSE To describe a precannulated fenestrated endograft system utilizing externalized guidewires to facilitate aortic arch endovascular repair and to report its use in 2 patients with challenging anatomy. TECHNIQUE For distal arch repair, a fenestration for the left subclavian artery (LSA) is made onsite in a standard thoracic endograft tailored to the patient anatomy; it is precannulated w...

BACKGROUND High blood pressure (BP) is among significant risk factor for stroke and other vascular occurrences, it experiences nonstop fluctuations over time as a result of a complex interface among cardiovascular control mechanisms. Large blood pressure variability (BPV) has been proved to be promising in providing potential regulatory mechanisms of the cardiovascular system. Although the prev...

Aging is associated with conduit artery stiffening that is a risk factor for and can precede hypertension and ventricular dysfunction. Increases in mitochondria DNA (mtDNA) frequency have been correlated with aging. Mice with a mutation in the encoding domain (D257A) of a proof-reading deficient version of mtDNA polymerase-γ (POLG) have musculoskeletal features of premature aging and a shortene...

Genetic and surgical mouse models are commonly used to study cerebrovascular disease, but their size makes invasive hemodynamic testing technically challenging. The purpose of this study was to demonstrate a noninvasive measurement of cerebrovascular impedance and wave reflection in mice using high-frequency ultrasound in the left common carotid artery (LCCA), and to examine whether microvascul...