A large number of neurodegenerative disorders are triggered by the aggregation of misfolded proteins called amyloids. The main pathogenic event in these proteinopathies is the accumulation of oligomers, soluble assemblies that can disrupt synaptic activity, alter intracellular signaling, and spread to neighboring cells. Thus, preventing the formation of oligomers is a common therapeutic strateg...

Despite the huge technological transformation of the global economy in the 20th Century, stabilization of greenhouse gas emissions will require a comparable revolutionary technological change in the 21st Century. While projections of future greenhouse gas (GHG) emissions show large increases in the coming century, the scenarios that underpin these projections already include major improvements ...