THE discovery of the antiviral properties of 5-iodo2'-deoxyuridine (IDU), arabinoside cytosine (ARAC), L-asparaginase and of some derivatives of rifampicin holds out new perspectives for the treatment of severe viral diseases, such as herpetic encephalitis and opportunistic viral illnesses in the immuno-depressed host. For these infections a valuable chemotherapeutic regimen still remains to be...

Despite of its effective anti-tumour activity,L-Asparaginase has limited clinical application due to the high rate of clinical hypersensitivity. In an attempt to develop a liposomal drug delivery for L-Asparaginase, enzyme loaded liposomes were formulated using soy lecithin, cholesterol and charge inducers by thin film hydration method. The effect of various components of the liposomes includin...

The aim of this investigation was to compare the efficacy of the permeabilization methods of microwave irradiation and potassium phosphate (KPi)-hexane solvent system in isolating the periplasmic enzyme, L-asparaginase II. Previous studies have shown that both methods enable the isolation of periplasmic proteins in Gram-negative bacteria. Periplasmic, cytoplasmic and membrane fractions of Esche...

One of the prime candidates in the treatment of debilitating human cancers includes a family of enzymes referred to as Lasparaginases. The efficacious antitumor activity of these enzymes finds use in countering Acute Lymphoblastic Leukemia (ALL), a commonly diagnosed pediatric cancer. The enzyme's use is merited by the high remission rate and fairly rapid response with therapeutic index (1000)....

L-asparaginase is an enzyme that catalyzes the conversion of L-asparagine to L-aspartate and ammonia. The important application of the L-asparaginase enzyme in using it as chemotherapeutic for its anticarcinogenic potential .In the present study a novel strain, AcinetobacterbaumanniiR7 was explored for the production of extracellular Lasparaginase .This enzyme was purified by single chromatogra...

An attempt is made in the present study to optimize the cultural conditions for the production of L-asparaginase by Fusarium oxysporum using submerged fermentation. Different fungal species were isolated and identified using standard manuals, screened initially for the production of extracellular L-asparaginase during their growth on Czapek’s Dox medium containing Lasparagine as sole source of ...

The antitumor activity of guinea 1'ig serum fractions was studied in vivo and in vitro by bright field, fluorescence, and electron microscopy observations and by dye permeability and cytidine-3H incorporation in 6C3HED lymphosarcoma cells. In C3H mice bearing the ascites tumor treated with the Lasparaginase fraction, there was a decrease in the total num ber and mitosis of tumor cells, a reduct...

Background: Hyperglycemia is a common side effect and it has long been recognized as consequence of corticosteroids L-asparaginase, chemotherapeutic agents key to ALL treatment. This study was done determine the frequency identify risk factors for hyperglycemia in paediatric during induction chemotherapy.
 Material & Methods: prospective observational among 87 newly diagnosed cases 1-1...

The antitumor activity of guinea 1'ig serum fractions was studied in vivo and in vitro by bright field, fluorescence, and electron microscopy observations and by dye permeability and cytidine-3H incorporation in 6C3HED lymphosarcoma cells. In C3H mice bearing the ascites tumor treated with the Lasparaginase fraction, there was a decrease in the total num ber and mitosis of tumor cells, a reduct...

L-asparaginase is an enzyme that catalyzes the conversion of L-asparagine to L-aspartate and ammonia. The important application of the L-asparaginase enzyme in using it as chemotherapeutic for its anticarcinogenic potential .In the present study a novel strain, AcinetobacterbaumanniiR7 was explored for the production of extracellular Lasparaginase .This enzyme was purified by single chromatogra...