نتایج جستجو برای: lasb

تعداد نتایج: 140  

Journal: :Angewandte Chemie 2021

Extrazelluläre Virulenzfaktoren haben sich als attraktive Ziele in der aktuellen Antibiotikaresistenzkrise erwiesen. Der Gram-negative Erreger Pseudomonas aeruginosa sezerniert den Virulenzfaktor Elastase B (LasB), eine wichtige Rolle im Infektionsprozess spielt. Hier berichten wir über einen submikromolaren, nicht-peptidischen, fragmentartigen Inhibitor von LasB, durch sorgfältige visuelle Ana...

2018
Vinciane Saint-Criq Bérengère Villeret Fabien Bastaert Saadé Kheir Aurélie Hatton Aurélie Cazes Zhou Xing Isabelle Sermet-Gaudelus Ignacio Garcia-Verdugo Aleksander Edelman Jean-Michel Sallenave

BACKGROUND Pseudomonas aeruginosa lung infections are a huge problem in ventilator-associated pneumonia, cystic fibrosis (CF) and in chronic obstructive pulmonary disease (COPD) exacerbations. This bacterium secretes virulence factors that may subvert host innate immunity. OBJECTIVE We evaluated the effect of P. aeruginosa elastase LasB, an important virulence factor secreted by the type II s...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه اصفهان - دانشکده فنی و مهندسی 1389

در این پایان نامه روش جدیدی برای پنهان نگاری داده در محیط های بلادرنگ تحت شبکه ارائه شده است. این فرآیند ترکیبی از روش های lsb وlack به نام (lasb) می باشد. با ترکیب این روش ها احتمال تشخیص داده ی پنهان شده به حداقل می رسد. برای فراهم آوردن محیط voip از پروتکل rtp استفاده شده و الگوریتم های lack ،lsb و lasb در محیط voip با استفاده از زبان برنامه نویسی c# پیاده سازی شده اند. برای پی بردن به کارای...

Journal: :Journal of bacteriology 2003
Florence Jude Thilo Köhler Pavel Branny Karl Perron Matthias P Mayer Rachel Comte Christian van Delden

Pseudomonas aeruginosa controls the secretion of extracellular virulence factors, including rhamnolipids and LasB elastase, by the las and rhl quorum-sensing systems. Here, we mutated the dksA gene of P. aeruginosa by insertion of an Omega-Hg cassette. The mutant displayed growth rates similar to that of the wild type in rich medium but was impaired in growth in defined minimal medium. Producti...

Journal: :Anesthesiology 2012
Srinivasa N Raja Rolf-Detlef Treede

The diagnosis of sympathetically maintained pain (SMP) is typically established by assessment of pain relief during local anesthetic blockade of the sympathetic ganglia that innervate the painful body part. To determine if systemic α-adrenergic blockade with phentolamine can be used to diagnose SMP, we compared the effects on pain of local anesthetic sympathetic ganglion blocks (LASB) and phent...

Journal: :Infection and immunity 1997
M J Preston P C Seed D S Toder B H Iglewski D E Ohman J K Gustin J B Goldberg G B Pier

The roles of the Pseudomonas aeruginosa proteases LasB (elastase) and LasA and the transcriptional activator LasR, which regulates the expression of these proteases, were evaluated in a murine model of P. aeruginosa corneal infection. In scarified corneas, P. aeruginosa PAO-A1 (LasA negative) or PAO-B1A1 (LasB and LasA negative) at a dose of 10(8) CFU per eye caused very mild or no disease foll...

Journal: :The Cochrane database of systematic reviews 2005
Tasha R Stanton Benedict M Wand Daniel B Carr Frank Birklein Gunnar L Wasner Neil E O'Connell

BACKGROUND This is an update of the original Cochrane review published in The Cochrane Library, 2005, Issue 4, on local anaesthetic blockade (LASB) of the sympathetic chain used to treat complex regional pain syndrome (CRPS). OBJECTIVES To assess the efficacy of LASB for the treatment of pain in CRPS and to evaluate the incidence of adverse effects of the procedure. SEARCH METHODS We update...

Journal: :Infection and immunity 1998
D G Storey E E Ujack H R Rabin I Mitchell

The role of Pseudomonas aeruginosa quorum-sensing systems in the lung infections associated with cystic fibrosis (CF) has not been examined. The purpose of this study was to determine if genes regulated by the LasR-LasI quorum-sensing system were coordinately regulated by the P. aeruginosa populations during the lung infections associated with CF. We also wanted to ascertain if there was a rela...

Sub Minimal Inhibitory concentrations (sub-MIC) of antibiotics, although not able to kill bacteria, can be effect on their physico- chemical characteristics and functions. This study aimed to investigate the effect of sub-MIC of imipenem and piperacillin on the transcriptional expression of virulence related genes algD and lasB in Pseudomonas auroginosa. Five clinical isolates of P. aeruginosa ...

2017
Comoé Koffi Donatien Benie Adjéhi Dadié Nathalie Guessennd Nadège Ahou N’gbesso-Kouadio N’zebo Désiré Kouame David Coulibaly N’golo Solange Aka Etienne Dako Koffi Marcellin Dje Mireille Dosso

Pseudomonas aeruginosa owns a variability of virulence factors. These factors can increase bacterial pathogenicity and infection severity. Despite the importance of knowledge about them, these factors are not more characterized at level of strains derived from local food products. This study aimed to characterize the virulence potential of P. aeruginosa isolated from various animal products. Se...

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