OBJECTIVE To determine whether the presence of laryngopharyngeal reflux symptoms is associated with the presence of esophageal adenocarcinoma (EAC). BACKGROUND Most patients diagnosed with EAC have incurable disease at the time of detection. The majority of these patients are unaware of the presence of Barrett's esophagus prior to cancer diagnosis and many do not report typical symptoms of ga...

Laryngopharyngeal reflux has been recognized since 2006 (Montreal Consensus) as an extradigestive manifestation of gastroesophageal reflux disease. However, despite numerous research studies, the relationship between these two pathologies is yet to be fully understood. The aim of this paper is to review the literature of the last five years available via the PubMed database, looking at the cont...

BACKGROUND/AIMS To establish an animal model of laryngopharyngeal reflux (LPR) and study the effect of LPR on the laryngopharyngeal mucosal ultrastructure. METHODS Ten Bama minipigs were randomly divided into control group and stent group. Every pig underwent endoscope, and baseline pH was monitored for 4 hours at laryngopharynx and distal esophagus, then specimens from laryngopharyngeal muco...

OBJECTIVES/HYPOTHESIS A literature review regarding the use of laryngopharyngeal mucosal signs in diagnosing laryngopharyngeal reflux (LPR). STUDY DESIGN Literature review. METHODS A search of MEDLINE in February 2012 using the terms laryngopharyngeal reflux, laryngitis, mucosa, appearances, and signs (English language only). RESULTS One or more laryngopharyngeal mucosal signs associated ...

CONTEXT Laryngopharyngeal reflux (LPR) is a major cause of laryngeal inflammation and presents with a constellation of symptoms different from classic gastroesophageal reflux disease. OBJECTIVE To provide a practical approach to evaluating and managing cases of LPR. EVIDENCE ACQUISITION The PubMed database and the Ovid Database of Systematic Reviews were systematically searched for laryngop...

BACKGROUND Laryngopharyngeal reflux disease can present with a varied symptomatology because of the involvement of multiple sub-sites of the upper aero-digestive tract. It is a very common disease to be encountered in routine practice by both medical and ENT personnel. Its association with multiple pathologies including malignancy warrants an early diagnosis and management. The lack of cost eff...

laryngopharyngeal reflux (lpr) is a variant of gastroesophageal reflux disease (gerd) in which the stomach contents go up into the pharynx and then down into the larynx. lpr causes a wide spectrum of manifestations mainly related to the upper and the lower respiratory system such as laryngitis, asthma, chronic obstructive pulmonary disease, cough, hoarseness, postnasal drip disease, sinusitis, ...

Introduction: Acid reflux disease of the larynx has been established as a separate clinical entity in the present day, requiring the nuances of a skilled laryngologist for its early diagnosis and appropriate management. Clinical presentations of laryngopharyngeal reflux disorder may vary from very subtle to mammoth proportions, ranging across a panorama of features like chronic laryngitis, indo...

1Department of Otolaryngology-Head Neck Surgery, Queen Alexandra Hospital, Portsmouth PO63LY, UK 2Department of Otolaryngology, Aristotle university of Thessaloniki, Thessaloniki, Greece 3Department of Otolaryngology-Head Neck Surgery, The Freeman Hospital, Newcastle Upon Tyne, UK 4Department of Otolaryngology-Head Neck Surgery, Schwarzwald-Baar Hospital, Villingen-Schwenningen, Germany 5Depart...