We investigated the neural and chemical mechanisms contributing to the immediate ventilatory responses to laryngeal exposure to wood smoke in anesthetized Sprague-Dawley rats. Five milliliters of wood smoke were delivered into a functionally isolated larynx at a constant flow rate of 1.4 ml/s while the animals breathed spontaneously. Within 1 s after exposure, laryngeal wood smoke consistently ...

introduction:  the aim of this study was to compare the preventive effects of corticosteroids and curcumin on subglottic stenosis in an animal model.  materials and methods: twenty-one male german shepherd dogs were used for this study. after standardized trauma to the subglottic area, the dogs were divided into three groups. group a received curcumin (450 mg/ day) for 15 days; group b received...

YY1 is a key transcription factor and plays different roles in various cancers. However, role and mechanism of YY1 in laryngeal cancer are still unknown. YY1 and MYCT1 mRNA and protein levels were detected by Real-time RT-PCR and Western Blot methods, respectively. Binding of YY1 to MYCT1 promoter was predicted and confirmed by bioinformatics and chromatin immunoprecipitation assays, respective...

BACKGROUND In laryngeal squamous cell carcinoma (SCC), CD133+ cells were found to display cancer stem cell (CSC) characteristics. BMI1 is an oncogene that plays key roles in proliferation in CSCs. However, no published reports have examined the role of BMI1 in laryngeal CSCs. METHODS Immunofluorescence staining confirmed the coexpression of BMI1 and CD133. After sorting, real-time polymerase ...

OBJECTIVES/HYPOTHESIS To determine if differences in objective measures of laryngeal function can meaningfully explain different levels of self-perceptions of effort or fatigue in patients with vocal fold paresis. STUDY DESIGN A retrospective chart review of 72 patients with vocal fold paresis diagnosed using laryngeal electromyography, who had either been observed (n=21), treated only by inj...

OBJECTIVE The present study was to investigate the effect of 1,25(OH)2D3 on the proliferation and apoptosis of Lscc-02 laryngeal squamous cell carcinoma cell line. METHOD Lscc-02 human laryngeal squamous cell carcinoma cell line was treated with 1,25(OH)2D3. Cell proliferation was evaluated by MTT assay, distribution of cell cycle and rate of apoptosis determined by flow cytometry, and cell m...

We report herein a case of laryngeal sarcoidosis that was refractory to systemic corticosteroids, but that improved spontaneously. A 49-year-old woman complained of dysphagia and hoarseness with accompanying edematous swellings of both arytenoid regions. She was referred to our hospital after systemic corticosteroid therapy failed to achieve any improvement. Laryngoscopy showed marked edema of ...

We know very little about how muscles and motor units in one region of the upper airway are impacted by adjustments in an adjacent airway region. In this case, the focus is on regulation of the expiratory airstream by the larynx and how changes in laryngeal aperture impact muscle motor unit activities downstream in the pharynx. We selected sound production as a framework for study as it require...

Waveform capnography was recommended as the most reliable method to confirm correct endotracheal tube or laryngeal mask airway placements. However, capnography may be unreliable during cardiopulmonary resuscitation and during low flow states. It may lead to an unnecessary removal of a well-placed endotracheal tube, re-intubation and interruption of chest compressions. Real-time upper airway (la...