نتایج جستجو برای: larse wg

تعداد نتایج: 3429  

Journal: :The British journal of nutrition 2010
Iain A Brownlee Carmel Moore Mark Chatfield David P Richardson Peter Ashby Sharron A Kuznesof Susan A Jebb Chris J Seal

Recommendations for whole-grain (WG) intake are based on observational studies showing that higher WG consumption is associated with reduced CVD risk. No large-scale, randomised, controlled dietary intervention studies have investigated the effects on CVD risk markers of substituting WG in place of refined grains in the diets of non-WG consumers. A total of 316 participants (aged 18-65 years; B...

Journal: :IEEE Trans. Computers 2015
Hayssam El-Razouk Arash Reyhani-Masoleh Guang Gong

The WG stream ciphers are based on the WG (Welch-Gong) transformation and possess proved randomness properties. In this paper we propose nine new hardware designs for the two classes of WG(29, 11) and WG-16. For each class, we design and implement three versions of standard, pipelined and serial. For the first time, we use the polynomial basis (PB) representation to design and implement the WG(...

Journal: :Development 2014
Sabine Schilling Sarah Steiner Dario Zimmerli Konrad Basler

The potent activity of Wnt/Wingless (Wg) signals necessitates sophisticated mechanisms that spatially and temporally regulate their distribution and range of action. The two main receptor components for Wg - Arrow (Arr) and Frizzled 2 (Fz2) - are transcriptionally downregulated by Wg signaling, thus forming gradients that oppose that of Wg. Here, we analyze the relevance of this transcriptional...

Journal: :Development 1998
D Lessing R Nusse

Patterning of the Drosophila embryo depends on the accurate expression of wingless (wg), which encodes a secreted signal required for segmentation and many other processes. Early expression of wg is regulated by the nuclear proteins of the gap and pair-rule gene classes but, after gastrulation, wg transcription is also dependent on cell-cell communication. Signaling to the Wg-producing cells is...

Journal: :Developmental biology 2002
Hideki Nakagoshi Tetsuya Shirai Yo-ichi Nabeshima Fumio Matsuzaki

Pattern formation during animal development is often induced by extracellular signaling molecules, known as morphogens, which are secreted from localized sources. During wing development in Drosophila, Wingless (Wg) is activated by Notch signaling along the dorsal-ventral boundary of the wing imaginal disc and acts as a morphogen to organize gene expression and cell growth. Expression of wg is ...

Journal: :The Journal of Cell Biology 1996
F Reichsman L Smith S Cumberledge

Wingless, the Drosophila homologue of the proto-oncogene Wnt-1, encodes a secreted glycoprotein that regulates differentiation and proliferation of nearby cells. Here we report on the biochemical mechanism(s) by which the wingless signal is transmitted from cell to cell. When expressed in S2 cells, the majority (approximately 83%) of secreted wingless protein (WG) is bound to the cell surface a...

2016
Go-Woon Kim Jong-Hoon Won Ok-Kyung Lee Sang-Soo Lee Jeong-Hoon Han Orkhon Tsogtbaatar Sujin Nam Yeon Kim Kyung-Ok Cho

ADAMTS (a disintegrin and metalloproteases with thrombospondin motif) family consists of secreted proteases, and is shown to cleave extracellular matrix proteins. Their malfunctions result in cancers and disorders in connective tissues. We report here that a Drosophila ADAMTS named Sol narae (Sona) promotes Wnt/Wingless (Wg) signaling. sona loss-of-function mutants are lethal and rare escapers ...

Journal: :Development 2004
Yi A Zeng Esther M Verheyen

The cellular events that govern patterning during animal development must be precisely regulated. This is achieved by extrinsic factors and through the action of both positive and negative feedback loops. Wnt/Wg signals are crucial across species in many developmental patterning events. We report that Drosophila nemo (nmo) acts as an intracellular feedback inhibitor of Wingless (Wg) and that it...

Journal: :Cell 1998
Kenneth M Cadigan Matthew P Fish Eric J Rulifson Roel Nusse

In Drosophila wing imaginal discs, the Wingless (Wg) protein acts as a morphogen, emanating from the dorsal/ventral (D/V) boundary of the disc to directly define cell identities along the D/V axis at short and long range. Here, we show that high levels of a Wg receptor, Drosophila frizzled 2 (Dfz2), stabilize Wg, allowing it to reach cells far from its site of synthesis. Wg signaling represses ...

Journal: :Cell 1996
Myriam Zecca Konrad Basler Gary Struhl

Wingless (Wg), a founding member of the Wingless/Int-1 (Wnt) family of secreted proteins, acts as a short-range inducer and as a long-range organizer during Drosophila development. Here, we determine the consequences of ectopically expressing (i) a wild-type form of Wg, (ii) a membrane-tethered form of Wg, and (iii) a constitutively active form of the cytosolic protein Armadillo (Arm), which no...

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