the manufacturing organizations today are having a competition of supply chain versus supply chain. existing research work fails to relate human metrics with supply chain performance. the authors intend to empirically assess the effects of human metrics on supply chain performance in the context of indian manufacturing organizations. a rigorous literature review has identified 12 variables. the...

In vascular smooth muscle, stimulation of heterotrimeric G protein-coupled receptors (GPCRs) by various contractile agonists activates intracellular signaling molecules to result in an increase in cytosolic Ca2+ and the subsequent phosphorylation of myosin light chain (MLC) by Ca2+/calmodulin-dependent MLC kinase. In addition, a portion of agonist-induced contraction is partially mediated by th...

nowadays, in turbulent and violate global markets an agile supply chain (asc) network is frequently considered as a dominant competitive advantage for survival. to achieve the competitive advantage, companies must align with suppliers and customers to streamline operations, as well as agility beyond individual companies. there are many definitions and models about agile supply chain and most of...

regarding to the diversified needs of domestic and global customers and various products of domestic and global competitors, importance of agility in supply chain management becomes more important. suppliers have to provide materials and essential resources of manufacturers in a short time without any lead time.in this research, we identified many criteria for agility in sanitation supply chain...

Semaphorins are axon guidance molecules that signal through the plexin family of receptors. Semaphorins also play a role in other processes such as immune regulation and tumorigenesis. However, the molecular signaling mechanisms downstream of plexin receptors have not been elucidated. Semaphorin 4D is the ligand for the plexin-B1 receptor and stimulation of the plexin-B1 receptor activates the ...

Directed migration is essential for cell motility in many processes, including development and cancer cell invasion. RSKs (p90 ribosomal S6 kinases) have emerged as central regulators of cell migration; however, the mechanisms mediating RSK-dependent motility remain incompletely understood. We have identified a unique signaling mechanism by which RSK2 promotes cell motility through leukemia-ass...

managing the supply chain plays an important role in creating competitive advantages for companies. adequate information flow in supply chain is one of the most important issues in scm. therefore, using certain information systems can have a significant role in managing and integrating data and information within the supply chain. pharmaceutical supply chain is more complex than many other supp...

Rho GTPases are integral to the regulation of actin cytoskeleton-dependent processes, including mitosis. Rho and leukemia-associated Rho guanine-nucleotide exchange factor (LARG), also known as ARHGEF12, are involved in mitosis as well as diseases such as cancer and heart disease. Since LARG has a role in mitosis and diverse signaling functions beyond mitosis, it is important to understand the ...