Langerhans' cells were studied in the epidermis of two patients with active Behçet's disease and compared with those in two normal controls. Ultrastructural morphology and the percentage of Langerhans' cells found were similar in patients' (1.88%) and the control epidermis (1.79%). The density of Langerhans' cells in adjacent sites of the same epidermis was not homogeneous, being in the range o...

Protozoan parasites of the genus Leishmania exist as obligatory intracellular amastigotes and invade macrophages and Langerhans cells, the dendritic cells of the skin. Langerhans cells are much more efficient in presenting Leishmania major antigen to T cells than macrophages are and have the unique ability to retain parasite antigen in immunogenic form for prolonged periods. To analyze the mech...

The effect of etretinate, applied systemically, on epidermal Langerhans cells was studied. The numbers and shapes of Langerhans cells were observed on split epidermis, and the percentage of Langerhans cells in whole epidermal cells was determined with a flow cytometrial system. On an epidermal sheet, the number of Langerhans cells changed biphasically, first the number increased, then decreased...

Langerhans cell sarcoma of the skin is a rare tumor with aggressive behavior. There are reports of Langerhans cell sarcoma involving the skin in patients with underlying systemic Langerhans cell histiocytosis. However, to our knowledge, sarcomatous transformation of skin Langerhans cell histiocytosis, has not been previously described. We report a case of Langerhans cell sarcoma of the skin rep...

background: langerhans' cell histiocytosis (lch) is a reactive proliferative disease of unknown pathogenesis characterized by proliferation of langerhans cells. involvement of bone marrow (bm), liver and lung are related to high risk factors and poor survival. the aim of this report is to highlight the clinical and haematological findings of 5 cases of lch with bm infiltration which may help to...

Langerhans cells are the dendritic cells typical of stratified squamous epithelia and enjoy an intermediate state of differentiation as dendritic cells, since they are very efficient in uptaking and processing antigens but poor in presenting them to lymphocytes. These cells, and other dendritic cells as well, differentiate from bone marrow precursors, with circulating monocytes as intermediates...

Despite the critical role of the Langerhans cells in the induction of contact hypersensitivity reactions, non-Langerhans antigen-presenting cells in already sensitized individuals may play a role in the elicitation phase of a contact hypersensitivity reaction. Following epicutaneous challenge with antigens, the number of CD1+DR+ epidermal Langerhans cells increased in a time-dependent way and, ...

Langerhans cell histiocytosis (LCH) merupakan salah satu penyakit terbanyak dari histiositosis dengan 2,0–5,4 kasus/100 juta populasi diseluruh dunia usia<15 tahun dan jarang terjadi pada dewasa. Penyakit ini bermanifestasi sebagai spektrum klinik gejala bervariasi mulai ringan, tersebar tubuh, bahkan bisa mengancam nyawa penderitanya. Klinisi ahli patologi dapat mengenali manifestasi klinis...

langerhans cell histiocytosis (lch) is the most common type of childhood histiocytic disorder with an incidence of 0.2 to 1 per 100,000 children under the age of 15 years (1). the clinical picture of lch varies from single system (s-s)bone or skin disease to multi-system disease (m-s) (2). we report a neonate with disseminated papulonodular eruption containing mononuclear cd1a and s100 positive...