Lamotrigine is a broad-spectrum antiepileptic drug that blocks sodium channels, thereby inhibiting the pre-synaptic release of excitatory neurotransmitters. The primary aim of the study was to evaluate lamotrigine add-on therapy and consecutive monotherapy in patients with epilepsy whose seizures were not controlled by carbamazepine or valproate. One hundred and twenty six epilepsy patients at ...

Introduction: Lamotrigine is an anti-epileptic drug indicated for the treatment of bipolar disorder and recurrent depressive disorders. Its efficacy has been demonstrated. However, its use may be limited by risk severe, life-threatening allergic reactions. Objectives And Methods: We report hereafter clinical case a patient suffering from depression treated with lamotrigine which induced skin al...

Lamotrigine is an antiepileptic drug used as a treatment for partial and generalised seizures as well as for bipolar disorder type I. Till date, very few cases of lamotrigine overdose have been reported. The spectra of clinical effects of lamotrigine in acute overdose are not well established. In severe cases of poisoning, serious effects such as coma, respiratory depression, recurrent seizures...

OBJECTIVE Little information is available on the need for dosage changes for lamotrigine in pregnant women with bipolar disorder. The authors present new data on serial serum levels of lamotrigine in pregnant patients on lamotrigine monotherapy. They also review the epilepsy literature on use of lamotrigine during pregnancy. METHOD Lamotrigine serum samples were obtained from eight mother-inf...

background: central post-stroke pain (cpsp) is a distressing pain syndrome, sometimes become refractory to the conventional pain managements. anticonvulsants have been used to alleviate different central pains. lamotrigine is a novel anticonvulsant and its proper dosage and its efficacy have not been well studied yet. the aim of this study was to evaluate the effect of 100 mg lamotrigine on ref...

Lamotrigine is an antiepileptic drug widely used to treat epileptic seizures. Using whole-cell voltage clamp recordings in combination with a fast drug application approach, we investigated the effects of lamotrigine on 5-hydroxytryptamine (5-HT)3 receptors in NCB-20 neuroblastoma cells. Co-application of lamotrigine (1~300 µM) resulted in a concentration-dependent reduction in peak amplitude o...

Lamotrigine is a first drug since lithium approved for maintenance treatment of bipolar type I. Lamotrigine-induced extrapyramidal side effects are rarely reported in literatures. In this letter, we have presented a case of Bipolar disorder which has induced dystonia to lamotrigine. Lamotrigine is a phenyltriazine derivative [1] which was originally approved by USA Food & Drug Administration fo...

This study was initiated to evaluate the long-term safety, tolerability and effect on seizure control of lamotrigine (Lamictal) in paediatric patients with epilepsy. A total of 155 children (aged 2-19 years) with treatment-resistant epilepsy received add-on therapy or monotherapy lamotrigine for up to four years. Patients had already experienced benefit from lamotrigine treatment in an open one...

BACKGROUND Lamotrigine is an anticonvulsant drug indicated for the maintenance treatment of bipolar I disorder and for various types of epilepsy. An orally disintegrating tablet (ODT) of lamotrigine was developed to provide a formulation option that might increase patient convenience and satisfaction. METHODS Subjects with mood disorders who reported difficulty swallowing currently prescribed...