Hydroxypyruvate has been shown to be an alternative substrate for lactate dehydrogenase. The clinical value of this “glycerate dehydrogenase’ has been investigated on 60 patients admitted to the hospital with a provisional diagnosis of myocardial infarction. For comparison, lactate dehyd rogenase, a-hydroxybutyric dehyd rogenase, creatine kinase, aspartate transaminase, and alanine transaminase...

how to cite this article: khosroshahi n, alizadeh p, khosravi m, salamati p, kamrani k. spinal fluid lactate dehydrogenase level differentiates between structural and metabolic etiologies of altered mental status in children. iran j child neurol. 2015 winter;9(1):31-36. abstract objective altered mental status is a common cause of intensive care unit admission in children. differentiating struc...

Commercially available diagnostic tools for the detection of lactate dehydrogenase elevating virus (LDV) infection have been restricted to measurement of serum lactate dehydrogenase (LDH) activity levels and detection of the viral genome by RT-PCR assays. Serologic diagnosis of LDV infection has not been widely adopted due to the belief that the formation of antigen-antibody complexes and B-cel...

introduction: the use of antioxidants before high-intensity training, which leads to the release of free radicals and muscle injuries, can result in reduced damage during exercise. accordingly, in this study, we aimed to evaluate the effect of selenium supplement intake on oxidative stress, following exhaustive aerobic exercise among young physically-active females. methods: in this quasi-exper...

objective(s): carbon nanotubes have unique mechanical, electrical, and thermal properties, with potential different applications in nanomedicine, electronics, and other industries. these new applications of carbon nanotubes in different industries lead to the increased exposure risk of nanomaterials to human. up to now, all aspects of carbon nanotubes toxicity are not completely clear following...

Both assays are accepted reference methods for measurement of lactate dehydrogenase (LDH) activity (2-4). At pH 7.4, pyruvate -* lactate (P -* L) activity is about three times lactate -+ pyruvate (L P) activity, because equilibrium favors formation of lactate. Normal range for the P -* L assay is 130-265 spectrophotometric units at 25#{176} (3); normal range for the L P assay is 40-98 units at ...

The Connecticut Department of Public Safety laboratory recently addressed a legal challenge to a hospital alcohol dehydrogenase (ADH)-based serum ethanol determination based on the suggestion of interference by lactate dehydrogenase (LDH)-catalyzed oxidation of lactate. Both ADH- and LDH-oxidations require NAD(+) (present in excess in the assay). NADH produced by LDH-catalyzed lactate oxidation...

A chimeric bifunctional enzyme composing of galactose dehydrogenase (galDH; from Pseudomonas fluorescens) and lactate dehydrogenase (LDH; from Bacillus stearothermophilus) was successfully constructed. The chimeric galDH/LDH possessed dual characteristics of both galactose dehydrogenase and lactate dehydrogenase activities while exhibiting hexameric rearrangement with a molecular weight of appr...