Bioassay-guided fractionation of hexane extracts of Gymnosperma glutinosum (Asteraceae) leaves, collected in North Mexico, afforded the known compounds hentriacontane (1) and (+)-13S,14R,15-trihydroxy-ent-labd-7-ene (2), as well as the new ent-labdane diterpene (-)-13S,14R,15-trihydroxy-7-oxo-ent-labd-8(9)-ene (3). In addition, D-glycero-D-galactoheptitol (4) was isolated from the methanolic ex...

Vascular plants invariably contain a class II diterpene cyclase (EC 5.5.1.x), as an entcopalyl diphosphate synthase is required for gibberellin phytohormone biosynthesis. This has provided the basis for evolution of a functionally diverse enzymatic family. A bifunctional diterpene synthase was characterized from the lycophyte Selaginella moellendorffii. The structure of its product, labda-7,13E...

CONTEXT Vitex negundo Linn. (Verbenaceae) seeds are pepper substitute and occasionally used as a condiment for edible purposes. The seeds also find use for analgesia, sedation, rheumatism and joint inflammation in folk medicine. OBJECTIVE To isolate and characterize bioactive constituents from V. negundo seeds. MATERIALS AND METHODS The ethanol extract of V. negundo seeds was subjected to r...

The first electrophilic α-amination reaction of labdane-type diterpene (−)-(5S,9S,10S,13S)-labd-7-en-15-oic acid and (+)-(5S,8R,9R,10S,13R)-8-hydroxylabdan-15-oic acid, isolated from aerial parts Ageratina jocotepecana is presented. In the presence dibenzylazodicarboxylate proline followed by an in situ reduction, corresponding hydrazino alcohols were obtained. It demonstrated that moiety had n...

The 80% aqueous acetone extract from the flowers of Hedychium coronarium was found to show a protective effect on D-galactosamine-induced cytotoxicity in primary cultured mouse hepatocytes. On the other hand, two new labdane-type diterpene glycosides, coronalactosides I (1) and II (2), and a new labdane-type trinorditerpene, coronadiene (3), were isolated together with 8 known compounds from th...

The genus Salvia is a valuable origin of structurally diverse terpenoids. In a project directed at structurally interesting bioactive metabolites from Iranian Salvia species, we studied Salvia reuterana. Two new labdane diterpene, 6β,14α-dihydroxy-15-acetoxysclareol (1), and 14α,15- dihydroxy sclareol (2), were isolated from the aerial part of the plant. Their structures were established mainly...

The genus Salvia is a valuable origin of structurally diverse terpenoids. In a project directed at structurally interesting bioactive metabolites from Iranian Salvia species, we studied Salvia reuterana. Two new labdane diterpene, 6β,14α-dihydroxy-15-acetoxysclareol (1), and 14α,15- dihydroxy sclareol (2), were isolated from the aerial part of the plant. Their structures were established mainly...

Two flavones, ladanein and 6-hydroxy-5,7,4′-trimethoxyflavone and one labdane-typediterpene, ent-13-epi-manoyloxide, were isolated from an ethyl acetate-methanol extract ofthe aerial parts of Salvia sharifii. The compounds were purified using several chromatographicmethods. Structural elucidation of the compounds was performed using their 1H and 13C-NMRdata, EI mass and UV spectral data. The co...