Recent findings have shown that malignant tumors contain cancer-initiating cells (CIC), which self-renew and are tumorigenic. However, CICs have not been characterized properly due to lack of specific markers. We recently established a mouse glioma cell line, NSCL61, by overexpressing an oncogenic HRas(L61) in p53-deficient neural stem cells. Using limiting dilution assays, we show that only 2 ...

We document the evolution of productivity in a steel mini mill with fixed capital, producing an unchanged product with Leontief technology working 24/7. Despite—almost—unchanged production conditions, output doubled within the sample period (12 years). We decompose the gains into downtime reductions, more rounds of production per time, and more output per run. After attributing productivity gai...

Using historical, ®rm-level data, this study compares the productivity of Japanese and U.S. integrated steel producers. In recent decades Japanese producers have demonstrated higher labor productivity than their U.S. counterparts, due largely to higher investment. Calculations of multifactor productivity suggest that the American ®rms, nevertheless, maintain a small advantage in overall ef®cien...

Expression of transforming Ha-Ras L61 in NIH3T3 cells causes profound morphological alterations which include a disassembly of actin stress fibers. The Ras-induced dissolution of actin stress fibers is blocked by the specific PKC inhibitor GF109203X at concentrations which inhibit the activity of the atypical aPKC isotypes lambda and zeta, whereas lower concentrations of the inhibitor which blo...

OBJECTIVE To examine whether oncogenic Ras affects transforming growth factor (TGF)-beta-mediated cell-cycle arrest in hematopoietic cells and the downstream signal transduction pathway involved in the interference with TGF-beta-induced cell-cycle arrest. MATERIALS AND METHODS Two leukemic cell lines bearing N-Ras(L61) mutations; HL-60 and TF-1, and the M1 cell line with wt Ras were investiga...

We report on new results in Witten’s cubic string field theory for the off-shell factor in the 4-tachyon amplitude that was not fully obtained explicitly before. This is achieved by completing the derivation of the Veneziano formula in the Moyal star formulation of Witten’s string field theory ~MSFT!. We also demonstrate a detailed agreement of MSFT with a number of on-shell and off-shell compu...

Sprouty negatively modulates branching morphogenesis in the Drosophila tracheal system. To address the role of mammalian Sprouty homologues in angiogenesis, another form of branching morphogenesis, a recombinant adenovirus engineered to express murine Sprouty-4 selectively in endothelial cells, was injected into the sinus venosus of embryonic day 9.0 cultured mouse embryos. Sprouty-4 expression...

Aim: The aim of this study was to analyze the differences in size maxillary and mandibular dental arch between Papuan males females. Materials Methods: An analytical cross-sectional design carried out 12 females aged above 18–25 years Surabaya. Raberin method used measure arches width cast transversal (L33, L66, L77) sagittal direction (L31, L61, L71). statistical analysis data normality by Kol...