Overexpression of the PED/PEA-15 protein in muscle and adipose cells increases glucose transport and impairs further insulin induction. Like glucose transport, protein kinase C (PKC)-alpha and -beta are also constitutively activated and are not further stimulatable by insulin in L6 skeletal muscle cells overexpressing PED (L6(PED)). PKC-zeta features no basal change but completely loses insulin...

Intraand inter-line transfers of blastocysts were performed between two lines of mice selected for high (H6) and low (L6) body weight at 6 weeks of age. A greater percentage of L6 blastocysts survived to term than did H6 blastocysts (7\m=.\8%,P < 0\m=.\01)and more L6 recipients littered than did the H6 recipients (19\m=.\7%,P < 0\m=.\01).A greater percentage of the mice born to the L6 recipient...

Both the skeletal muscle myoblast cell line L6 and an adhesion-deficient variant of L6 released glycoprotein complexes, termed adherons, into their culture medium. The adherons from the variant, M3A, differed from those of L6 in a number of properties. M3A adherons were much less effective in promoting the cell-substratum and cell-cell adhesion of myoblasts than L6 particles. The adherons from ...

To interpret visual-motion events, the underlying computation must involve internal reference to the motion status of the observer's head. We show here that layer 6 (L6) principal neurons in mouse primary visual cortex (V1) receive a diffuse, vestibular-mediated synaptic input that signals the angular velocity of horizontal rotation. Behavioral and theoretical experiments indicate that these in...

Layer 6 corticothalamic neurons are thought to modulate incoming sensory information via their intracortical axons targeting the major thalamorecipient layer of the neocortex, layer 4, and via their long-range feedback projections to primary sensory thalamic nuclei. However, anatomical reconstructions of individual layer 6 corticothalamic (L6 CT) neurons include examples with axonal processes r...

Layer 6 (L6) pyramidal neurons are the only neocortical pyramidal cell type whose apical dendrite terminates in layer 4 rather than layer 1. Like layer 5 pyramidal neurons, they participate in a feedback loop with the thalamus and project to other cortical areas. Despite their unique location in the cortical microcircuit, synaptic integration in dendrites of L6 neurons has never been investigat...

Sensory processing must be sensitive enough to encode faint signals near the noise floor but selective enough to differentiate between similar stimuli. Here we describe a layer 6 corticothalamic (L6 CT) circuit in the mouse auditory forebrain that alternately biases sound processing toward hypersensitivity and improved behavioral sound detection or dampened excitability and enhanced sound discr...

We obtain global well-posedness, scattering, uniform regularity, and global L6 t,x spacetime bounds for energy-space solutions to the defocusing energy-critical nonlinear Schrödinger equation in R×R4. Our arguments closely follow those of Colliender, Hoel, et al., though our derivation of the frequency-localized interaction Morawetz estimate is somewhat simpler. As a consequence, our method yie...

STUDY DESIGN In vitro biomechanical investigation of lumbosacropelvic spinal instrumentation. OBJECTIVE Determine whether unilateral iliac fixation, with or without an L6 to S1 interbody graft, provides equivalent biomechanical stability compared with bilateral iliac fixation. SUMMARY OF BACKGROUND DATA Recent clinical evidence has shown improved clinical outcomes of unilateral iliac fixati...

BACKGROUND Myoblast sheet transplantation is a promising novel treatment for ischemic heart failure. The aim of this study was to test the hypothesis that heat shock (HS) pre-treatment affects the angiogenic properties of myoblast sheets in vivo and in vitro. MATERIAL/METHODS We studied HS preconditioning of L6 myoblast sheets in relation to their apoptosis, proliferation, and vascular endoth...