نتایج جستجو برای: ku

تعداد نتایج: 7189  

Journal: :The Journal of biological chemistry 1991
G May C Sutton H Gould

The octamer motif (ATTTGCAT) is an important regulatory element in eukaryotic gene expression. A previously unidentified protein that recognizes this motif has been isolated from the human B cell line, Daudi. The protein, which we term Ku-2, bears a close resemblance to the DNA-binding autoantigen Ku. Like Ku, it is a heterodimer with subunits of 83 and 72 kDa; antisera raised against either su...

Journal: :Molecular and cellular biology 1996
S H Yang A Nussenzweig L Li D Kim H Ouyang P Burgman G C Li

Previously, we proposed a dual control mechanism for the regulation of the heat shock response in mammalian cells: a positive control mediated by the heat shock transcription factor HSF1 and a negative control mediated by the constitutive heat shock element-binding factor (CHBF). To study the physiological role of CHBF in the regulation of heat shock response, we purified CHBF to apparent homog...

Journal: :Seminare 2023

Najprościej ujmując pojęcie wartości, można uznać, że określa ono to, co dla człowieka jest ważne i cenne. Prezentowany tekst zawiera refleksje na temat istoty pojęcia wartości oraz różnego rozumienia tego pojęcia. Wskazano w nim także drogi wychowania do najwyższych, społecznych pozytywnych utylitarnych. Faktem jednak jest, iż we współczesnym świecie, zwłaszcza wśród młodych ludzi, dominują he...

Journal: :EMBO reports 2016
Assala Lamaa Morgane Le Bras Nicolas Skuli Sébastien Britton Philippe Frit Patrick Calsou Hervé Prats Anne Cammas Stefania Millevoi

Ku heterodimer is a DNA binding protein with a prominent role in DNA repair. Here, we investigate whether and how Ku impacts the DNA damage response by acting as a post-transcriptional regulator of gene expression. We show that Ku represses p53 protein synthesis and p53-mediated apoptosis by binding to a bulged stem-loop structure within the p53 5' UTR However, Ku-mediated translational repress...

Journal: :Molecular cancer therapeutics 2009
Sarah E Golding Elizabeth Rosenberg Nicholas Valerie Isa Hussaini Mark Frigerio Xiaoling F Cockcroft Wei Yee Chong Marc Hummersone Laurent Rigoreau Keith A Menear Mark J O'Connor Lawrence F Povirk Timothy van Meter Kristoffer Valerie

Ataxia telangiectasia (A-T) mutated (ATM) is critical for cell cycle checkpoints and DNA repair. Thus, specific small molecule inhibitors targeting ATM could perhaps be developed into efficient radiosensitizers. Recently, a specific inhibitor of the ATM kinase, KU-55933, was shown to radiosensitize human cancer cells. Herein, we report on an improved analogue of KU-55933 (KU-60019) with K(i) an...

Journal: :Communications in Mathematics and Applications 2023

In this paper, the notation of interior KU-algebra and some related definitions are introduced. Various characterisations for have been proved. The concept positive implicative prove results regarding also presented. addition, KU-ideals several properties these ideals

2015
Carmen de Sena-Tomás Eun Young Yu Arturo Calzada William K. Holloman Neal F. Lue José Pérez-Martín

The Ku heterodimer serves in the initial step in repairing DNA double-strand breaks by the non-homologous end-joining pathway. Besides this key function, Ku also plays a role in other cellular processes including telomere maintenance. Inactivation of Ku can lead to DNA repair defects and telomere aberrations. In model organisms where Ku has been studied, inactivation can lead to DNA repair defe...

Journal: :The Journal of Experimental Medicine 1995
A K Ajmani M Satoh E Reap P L Cohen W H Reeves

The Ku autoantigen is a heterodimer of 70- and 80-kD proteins recognized by autoantibodies from patients with systemic lupus erythematosus and related diseases that is the DNA-binding component of a DNA-dependent protein kinase. The catalytic activity of DNA-dependent protein kinase is carried by a 350-kD subunit (p350). In light of the recently described role of Ku in repairing double-strand D...

Journal: :Clinical chemistry 1997
J M Bonfrer C M Korse R A Verstraeten G J van Kamp G A Hart P Kenemans

The Byk LIA-mat CA125 II assay was compared with the Centocor IRMA CA125 II. Serum samples studied (n = 1012) were obtained from 652 apparently healthy females, 61 pregnant women, and 299 patients with benign and malignant gynecological tumors. The CA125 II assay value at the 95th percentile of the total healthy group was 29 kU/L for the LIA-mat and 32 kU/L for the Centocor assay. For the LIA-m...

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