A full-length mouse cDNA clone encoding KLF4 was initially isolated from a NIH3T3 cDNA library by reduced stringency screening with a DNA probe containing the zinc finger region of an immediate early gene product, Zif268 or Egr1. A distinct feature of the KLF4 gene is the highly GC-rich nature of the sequence near its 5'-end. Thus, the G+C content of the 1000 nt 5'-flanking region is 67% and th...

KLF5 is a transcription factor. Many KLF5 target genes, such as PDGFa, PPARg, NFkB, cyclinD1, KLF4, and TCR, have been identified in different cell models. KLF5 regulates cell proliferation, cell cycle, apoptosis, and differentiation. KLF5 is an important transcription factor for cardiovascular remodeling and tumor angiogenesis. KLF5 is essential for mouse embryo development. Additionally, KLF5...

Mukhopadhyay D, Jain MK. Inhibition of VPF/VEGF-mediated angiogenesis by the Kruppel-like factor KLF2. J Biol Chem 2005;280:28848–28851. 26. Kawanami D, Mahabeleshwar GH, Lin Z, Atkins GB, Hamik A, Haldar SM, Maemura K, LaManna JC, Jain MK. Kruppel-like factor 2 inhibits hypoxia-inducible factor 1{alpha} expression and function in the endothelium. J Biol Chem 2009;284: 20522–20530. 27. Urbich C...