PURPOSE Resistance to anti-HER2 monoclonal antibody trastuzumab is a relevant issue in breast cancer patients. Among the mechanisms implicated in trastuzumab resistance, increasing evidence supports a role of tumor microenvironment. We previously found that a novel toll-like receptor 9 agonist, referred to as immune modulatory oligonucleotide (IMO) and currently under clinical investigation, ac...

The early detection of HER2 (human epidermal growth factor receptor 2) status in breast cancer patients is very important for the effective implementation of anti-HER2 antibody therapy. Recently, HER2 detections using antibody conjugated quantum dots (QDs) have attracted much attention. QDs are a new class of fluorescent materials that have superior properties such as high brightness, high resi...

Previous studies have shown that people understand the future ancillary cost of durable goods such as an automotive vehicle. However, consumers tend to misunderstand benefits and costs these goods. One most interesting discussions about consumer cognitive ability for energy is miles per gallon (MPG) illusion. In this study, we analyze people’s misunderstanding relationship between kilometers li...

Stopped-flow spectrophotometry and e.p.r. spectroscopy were used to study the kinetics of reduction by dithionite of the oxidized Fe protein of nitrogenase from Klebsiella pneumoniae (Kp2.0 ) in the presence of MgADP at 230C at pH7.4. The active reductant, SO2-, produced by the predissociation of S2042= 2SO2-, reacts with Kp20. (MgADP),, with k 3.0 x 106 + 0.4 x 106 M-l' s-1. The inhibition of ...

The purpose of this article is to introduce King Pro League (KPL) in the Chinese E-sports industry and discuss its digital marketing strategies through case analysis. KPL was born 2016, based on China’s most popular cell phone MOBA game, Glory King, also became largest league China. reaches 73 billion views 2020, while 0.1 daily active players. reviews background growth China recent years, as w...

In this work captopril an antihypertensive (KPL) drug, was investigated using thermal analysis (TA) measurements (TG-DTA) in comparison with electron impact (EI) mass spectral (MS) fragmentation at 70 eV. Semi-empirical molecular (MO) calculations, using PM3 method in the neutral and positively charged forms of the drug. These include molecular geometry, bond order, charge distribution, heats o...

The distribution of phospholipids (PL) within the fat and serum phase ice cream manufacturing was evaluated through partition coefficients (KPL) after mixing, pasteurization, freezing, hardening. Ice creams containing about 40.41 ± 3.45 (control formulation) 112.29 9.06 (enriched PL mg per g were formulated with nonfat dry milk β-serum, respectively. Overall, KPL lower than 1, indicating that p...

Background and Aim: To investigate the radiopacity of different luting, lining and filling dental cements used in prosthetic dentistry in comparison with human and bovine dental hard tissues. Material and methods: Eight cylindrical samples of each material (6 x 1 mm) were prepared from Aqualox (APC), Durelon (DE) and Adhesor Carbofine (ACF) zinc polycarboxylate cements, Cavex zinc oxide eugenol...

Multilayered, core/shell nanoprobes (MQQ-probe) based on magnetic nanoparticles (MNPs) and quantum dots (QDs) have been successfully developed for multimodality tumor imaging. This MQQ-probe contains Fe(3)O(4) MNPs, visible-fluorescent QDs (600 nm emission) and near infrared-fluorescent QDs (780 nm emission) in multiple silica layers. The fabrication of the MQQ-probe involves the synthesis of a...