This paper introduces KL-Conc language, a Knowledge Representation Language based on KL-Magma, which is a version of KL-ONE. The aim of KL-Conc is to simulate conceptual operations underlying natural language. Relationships and differences between KL-Conc and KL-ONE are also discussed.

In an attempt to identify the histological properties of the klotho-deficient (kl/kl) bone matrix, bone mineralization and the localization of Ca(2+)-binding bone matrix proteins - osteocalcin, dentin matrix protein-1 (DMP-1) and matrix Gla protein (MGP) - were examined in kl/kl tibiae. While a widespread osteocalcin staining could be verified in the wild-type bone matrix, localization of the s...

Klotho, a protein mainly expressed in kidney and cerebral choroid plexus, is a powerful regulator of 1,25(OH)2D3 formation. Klotho-deficient mice (kl/kl) suffer from excessive plasma 1,25(OH)2D3-, Ca(2+)- and phosphate-concentrations, leading to severe soft tissue calcification and accelerated aging. NH4Cl treatment prevents tissue calcification and premature ageing without affecting 1,25(OH)2D...

Recent studies have demonstrated that klotho protein plays a role in calcium/phosphate homeostasis. The goal of the present study was to investigate the regulation of Na-P(i) cotransporters in klotho mutant (kl/kl) mice. The kl/kl mice displayed hyperphosphatemia, high plasma 1,25(OH)(2)D(3) levels, increased activity of the renal and intestinal sodium-dependent P(i) cotransporters, and increas...

this investigation aimed to assess genetics of body conformation and feed efficiency traits in a control line of rhode island red (rir) chicken taking single hatched out pedigreed 100 chicks at central avian research institute, izatnagar, india. data was analyzed by least squares analysis of variance. least squares means of chick weight (cw), body weight (bw), shank length (sl), keel length (kl...

Klotho (KL) is described as an anti-aging gene because mutation of Kl gene leads to multiple pre-mature aging phenotypes and shortens lifespan in mice. Growing evidence suggests that an increase in KL expression may be beneficial for age-related diseases such as arteriosclerosis and diabetes. It remains largely unknown, however, how Kl expression could be induced. Here we discovered novel molec...

Klotho (KL) expression is down-regulated in the renal tissues of chronic kidney disease (CKD) animal models and patients with end-stage renal disease. The putative role of KL promoter hypermethylation in the progression of CKD remains unclear. The present study aimed to determine renal and peripheral blood mononuclear cells (PBMC) levels of KL promoter methylation and analyze their relationship...

PURPOSE Dmp1 (dentin matrix protein1) null mice (Dmp1(-/-)) display hypophosphatemic rickets with a sharp increase in fibroblast growth factor 23 (FGF23). Disruption of Klotho (the obligatory co-receptor of FGF23) results in hyperphosphatemia with ectopic calcifications formed in blood vessels and kidneys. To determine the role of DMP1 in both a hyperphosphatemic environment and within the ecto...

We analyze KL lepton pair decays of KL → l+l−γ and KL → l+l−l′+l′− (l, l = e, μ) within the framework of the light-front model. With the KL → γγ form factors evaluated in the model, we calculate the decay branching ratios and we find out that our results are all consistent with the experimental data. In addition, we study KL → l+l− decays. We point out that our prediction on KL → e+e− is about ...