Recent meta-analyses and publications over the past 15 years have provided evidence showing there are considerable gender differences in the pharmacokinetics of metoprolol. Throughout this time, there have not been any research articles proposing a gender stratified dose-adjustment resulting in an equivalent total drug exposure. Metoprolol pharmacokinetic data was obtained from a previous publi...

In this paper, we propose and validate a multiscale model for the description of particle diffusion in presence trapping boundaries. We start from drift-diffusion equation which drift term describes effect bubble traps is modeled by short-range potential with an attractive repulsive core. The interaction particles attracted surface simulated Lennard–Jones that simplifies capture due to hydropho...

In literature on chemistry education it has often been suggested that students, at high school level and beyond, can benefit in their studies of chemical kinetics from computer supported activities. Use of system dynamics modeling software is one of the suggested quantitative approaches that could help to develop students’ knowledge about chemical kinetics and chemical equilibrium and to remedi...

the potential of bulk starter fermentation strategy for production of a cost-effective and safe source of β-galactosidase was investigated. three different bulk starter media with different compositions were selected, and an industrial yogurt starter culture strain, l. bulgaricus dsm 20081 was cultivated in these media under ph-controlled conditions (ph=5.6) at 43°c. the media consisted of 1) b...