objective(s)ischemia-reperfusion injury (iri) is a leading cause of kidney transplantation failure, and ischemic-preconditioning (ipc) is a protective method against the iri. in the present study, the defensive effect of ipc on rats’ kidney was investigated and more importantly the differences between two genders were appraised.materials and methodsthirty two wistar rats were randomly allocated...

background: rhabdomyolysis is one of the major complications of poisoning caused by alcohol, narcotics, and psychotropic substances acute toxicity, which might lead to acute renal failure and even death. this study aimed to evaluate clinical and laboratory findings of rhabdomyolysis syndrome in poisoning patients who were admitted to poisoning ward of farshchian hospital of hamadan, iran. metho...

background early predictive biomarkers for acute kidney injury (aki) such as neutrophil elatinase-associated lipocalin (ngal) could identify patients who may benefit from early initiation of treatment. objectives we aimed to obtain a cut off point for aki prediction by urine ngal in kidney transplantation. patients and methods in a prospective cohort study, 64 adult who underwent kidney transpl...

background: l-carnitine may prevent the incidence of aki by its antioxidant effects and improving circulation in ischemic conditions. the goal of this trial was to evaluate the impact of l-carnitine on contrast-induced nephropathy in patients undergoing elective pci. methods: totally, the patients were randomly allocated to 2 groups. the treatment group received 1 g of l-carnitine orally 3 time...

background: acute kidney injury (aki) has been recognized as one of the most complex clinical complications in modern medicine, and ischemia/reperfusion (i/r) injury is well-known as a main reason of aki. in addition, aki leads to important systemic consequences such as acute lung injury. this study was designed to investigate the role of erythropoietin (epo) on kidney function makers and tissu...

background bone morphogenetic protein 7 (bmp7) has been suggested to play a protective role against kidney injury in chronic kidney disease. objectives to identify the critical molecular regulators in the early stage of diabetic nephropathy, we studied the expression of bmp7 and 2 important kidney-specific markers, podocin and tamm–horsfall protein (thp). materials and methods a diabetic nephro...

background: acute kidney injury (aki) is a common problem in critically ill patients and is independently associated with increased morbidity and mortality. recently, serum cystatin c has been shown to be superior to creatinine in early detection of renal function impairment. we compared estimated gfr based on serum cystatin c with estimated gfr based on serum creatinine for early detection of ...

background: hair dye poisoning, with main toxic component paraphenylene diamine, is a medical emergency. it is on increasing trend in developing countries due to wide availability and low cost of hair dyes. it carries a high mortality and does not have any specific antidote. case report:  twenty three years old patient presented with breathelessness along with difficulty in speaking for one hou...

conclusions aki is common in urology patients. the underlying aetiologies of aki in this group may explain a lower overall mortality, although increasing aki severity remains a marker of patients at higher risk of poor outcomes. the low rate of renal recovery suggests that urology patients who sustain aki are exposed to a significant risk of ckd and its attendant consequences for long term heal...

background exertional heat stroke (ehs) is still a main cause of death in sport. many of ehs complications could have been prevented if ehs had been recognized and treated early and properly. case presentation we report an unusual case of multiple organ failure caused by ehs due to intensive sportive activities in a hot environment with lack of primary care. a 35-year-old healthy sportive man w...