نتایج جستجو برای: keywords harmine

تعداد نتایج: 1978292  

2013
Mohamed A. M. El Gendy Ayman O. S. El-Kadi

We previously demonstrated that Peganum harmala L. extract and its main active constituents, harmine and harmaline inhibit the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-mediated induction of the carcinogen-activating enzyme, Cyp1a1, in vitro. However, the effect of both alkaloids on Cyp1a1 in vivo has not been investigated. Therefore, the aim of this study is to examine the effect of harmine a...

2017
Nan Zou Yue Wei Fenghua Li Yang Yang Xuemei Cheng Changhong Wang

BACKGROUND Compound Muniziqi granule (MNZQ) is a multi-component herbal preparation and a popular traditional Uighur medicine used in China for treating endocrine disorder-induced acne, chloasma, dysmenorrhea, menopausal syndrome, and melanoma. Harmine presented in MNZQ has been confirmed potential anticancer effect on the B16 cells among others. The purpose of this study is to explore the inhi...

Journal: :Biological & pharmaceutical bulletin 2014
Daisuke Kondoh Saori Yamamoto Tatsunosuke Tomita Koyomi Miyazaki Nanako Itoh Yuki Yasumoto Hideaki Oike Ryosuke Doi Katsutaka Oishi

The circadian clock is a cell-autonomous endogenous system that generates circadian rhythms in the behavior and physiology of most organisms. We previously reported that the harmala alkaloid, harmine, lengthens the circadian period of Bmal1 transcription in NIH 3T3 fibroblasts. Clock protein dynamics were examined using real-time reporter assays of PER2::LUC to determine the effects of harmine ...

احمدنژاد, محرم, سلیمانی ثمرخزان, حامد, نوروزی عقیده, علی,

Introduction: Epigenetic changes such as promoter methylation of tumor suppressor genes (TSGs) is one of the most important mechanisms involved in the development of hematologic malignancies. Harmine is one of the Harmal-derived alkaloids with anti-proliferatory effects on leukemia cell lines. Since P16 and DAPK genes are hypermethylated in some hematologic malignancies, the current study aimed...

2016
Vanja Dakic Renata de Moraes Maciel Hannah Drummond Juliana M. Nascimento Pablo Trindade Stevens Rehen

Harmine is a β-carboline alkaloid present at highest concentration in the psychotropic plant decoction Ayahuasca. In rodents, classical antidepressants reverse the symptoms of depression by stimulating neuronal proliferation. It has been shown that Ayahuasca presents antidepressant effects in patients with depressive disorder. In the present study, we investigated the effects of harmine in cell...

Journal: :Molecular cancer research : MCR 2017
Zachary A Yochum Jessica Cades Lucia Mazzacurati Neil M Neumann Susheel K Khetarpal Suman Chatterjee Hailun Wang Myriam A Attar Eric H-B Huang Sarah N Chatley Katriana Nugent Ashwin Somasundaram Johnathan A Engh Andrew J Ewald Yoon-Jae Cho Charles M Rudin Phuoc T Tran Timothy F Burns

TWIST1, an epithelial-mesenchymal transition (EMT) transcription factor, is critical for oncogene-driven non-small cell lung cancer (NSCLC) tumorigenesis. Given the potential of TWIST1 as a therapeutic target, a chemical-bioinformatic approach using connectivity mapping (CMAP) analysis was used to identify TWIST1 inhibitors. Characterization of the top ranked candidates from the unbiased screen...

2013
Jonathan Ott

Summarized are psychonautic bioassays (human self-experiments) of pharmaiiopo­ crystalline bufotenine (5-HO-DMT; 5-hydroxy-N,N-dimethyltryptamine; dimethylserotonine), at times combined with harmaline or harmine-via intranasal, sublingual, intrarectal, pulmonary (inhaled vapor) and oral routes. This is done by way of pharmacological modeling of diverse South American shamanic inebriants, princi...

2016
Vanja Dakic Renata de Moraes Maciel Hannah Drummond Juliana M. Nascimento Pablo Trindade Stevens K. Rehen

Harmine is the β-carboline alkaloid with the highest concentration in the psychotropic plant decoction Ayahuasca. In rodents, classical antidepressants reverse the symptoms of depression by stimulating neuronal proliferation. It has been shown that Ayahuasca presents antidepressant effects in patients with depressive disorder. In the present study, we investigated the effects of harmine in cell...

Journal: :علوم پیراپزشکی و بهداشت نظامی 0
علی نوروزی عقیده ali noroozi aghide department of laboratory science, faculty of paramedicine. aja university of medical science, tehran, iranگروه علوم آزمایشگاهی، دانشکده پیراپزشکی، دانشگاه علوم پزشکی ارتش، تهران، ایران حامد سلیمانی ثمرخزان hamed soleimani samarkhazan department of hematology, faculty of paramedicine, tehran university of medical science, tehran, iranگروه هماتولوژی، دانشکده پیراپزشکی، دانشگاه علوم پزشکی تهران، تهران، ایران محرم احمدنژاد moharam ahmadnezhad department of hematology, blood transmission organization, tehran, iranگروه هماتولوژی، سازمان انتقال خون ایران، تهران، ایران

introduction: epigenetic changes such as promoter methylation of tumor suppressor genes (tsgs) is one of the most important mechanisms involved in the development of hematologic malignancies. harmine is one of the harmal-derived alkaloids with anti-proliferatory effects on leukemia cell lines. since p16 and dapk genes are hypermethylated in some hematologic malignancies, the current study aimed...

2012
Fujun Dai Yihua Chen Yajuan Song Li Huang Dong Zhai Yanmin Dong Li Lai Tao Zhang Dali Li Xiufeng Pang Mingyao Liu Zhengfang Yi

Activation of p53 effectively inhibits tumor angiogenesis that is necessary for tumor growth and metastasis. Reactivation of the p53 by small molecules has emerged as a promising new strategy for cancer therapy. Several classes of small-molecules that activate the p53 pathway have been discovered using various approaches. Here, we identified harmine (β-carboline alkaloid) as a novel activator o...

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