The response of 73 psychiatric outpatients to manipulation of their dietary intake of carbohydrate was studied with respect to symptoms of anxiety, depression, and dys-perception. In particular these symptoms were evaluated in three conditions: in ketosis, at the transition point from ketosis to non-ketosis, which I regard as an "Optimum Carbohydrate Level" (OCL), and at a higher carbohydrate i...

The pituitary, adrenal, and other endocrine glands are generally assumed to play a critical, or even indispensable role in the development of ketosis. However, a previous study demonstrated that in the rat neither the hypophysis nor the adrenal Awas essential for ketosis during a prolonged fast (1), although they did influence the magnitude of the ketonemia and recovery therefrom as the fast wa...

To establish a method to predict postpartum diseases using prepartum back fat thickness (BFT), the peripartum BFTs of 54 healthy multiparous cows before calving, which were diagnosed with postpartum displacement of the abomasum (DA), clinical ketosis or subclinical ketosis were compared with those of healthy cows from 8 weeks before the expected calving date to 8 weeks after calving. The peripa...

Ketosis-prone type 2 diabetes is a unique and underrecognized clinical entity characterized by new adult onset of diabetes with severe hyperglycemia and ketosis similar to type 1 diabetes, but with clinical and biological features typical of type 2 diabetes (1). Hyperglycemic crisis with ketosis in these individuals appears to be related to acute and reversible b-cell dysfunction with subsequen...

BACKGROUND The features of carotid atherosclerosis in ketosis-onset diabetes have not been investigated. Our aim was to evaluate the prevalence and clinical characteristics of carotid atherosclerosis in newly diagnosed Chinese diabetic patients with ketosis but without islet-associated autoantibodies. METHODS In total, 423 newly diagnosed Chinese patients with diabetes including 208 ketosis-o...

Neuroprotective properties of ketosis may be related to the upregulation of hypoxia inducible factor (HIF)-1alpha, a primary constituent associated with hypoxic angiogenesis and a regulator of neuroprotective responses. The rationale that the utilization of ketones by the brain results in elevation of intracellular succinate, a known inhibitor of prolyl hydroxylase (the enzyme responsible for t...

BACKGROUND The clinical features of atherosclerotic lesions in ketosis-onset diabetes are largely absent. We aimed to compare the characteristics of lower limb atherosclerotic lesions among type 1, ketosis-onset and non-ketotic type 2 diabetes. METHODS A cross-sectional study was performed in newly diagnosed Chinese patients with diabetes, including 53 type 1 diabetics with positive islet-ass...

Both the cow and the sheep are susceptible to ketosis. In the cow the clinical condition is termed primary spontaneous bovine ketosis and in the sheep, pregnancy toxaemia. Bovine ketosis occurs typically in the third to eighth week of lactation in mature heavily lactating diary cows. Pregnancy toxaemia occufs in late pregnancy in ewes bearing two or more lambs. Both conditions are associated wi...

It is well known that in most human subjects ketosis appears -when the material metabolized becomes restricted to protein and fat. This condition is observed after several days of fasting, on diets deficient in carbohydrate, and in diabetes in consequence of the loss of ability to metabolize carbohydrate. These facts have led to the view that a certain minimum combustion of carbohy,drate is nec...