OBJECTIVE To test the hypothesis that high concentrations of extracellular inorganic pyrophosphate (PPi), which associate with increased cell synthesis and turnover in cartilage, may act as a marker for structural outcome in knee osteoarthritis (OA). METHOD One hundred and thirty five consecutive patients referred to hospital with knee OA (59 men, 76 women; mean age 71 years, range 41-88) wer...

The aim of this study was to investigate the relationship between the biochemical markers of arthritis and the radiographic grading of osteoarthritis (OA) in knees. Seventy-one women aged 49-85 years with knee OA were studied. Anterior-posterior knee radiographs and hand radiographs were taken in all patients. The radiographic grading of OA in the knee was performed by using the Kellgren-Lawren...

Objectives. The aim of this study was to investigate the relationships between pain, disability, and radiographic findings in patients with knee osteoarthritis (OA). Patients and Methods. A total of 114 patients with knee OA who attended the physical medicine and rehabilitation outpatient clinic were included in this study. The diagnosis was based on the American College of Rheumatology (ACR) c...

BACKGROUND Closing-wedge high tibial osteotomy (HTO) is successful for the treatment of medial osteoarthritis with varus malalignment. Preoperative risk factors for HTO failure are still controversial. The aim of this study was to elucidate the outcome and assess the influence of risk factors on long term HTO survival. METHODS 199 patients were retrospectively studied with a mean follow-up pe...

The primary aim of this study is to document whether patellofemoral arthroplasty is a good treatment option for patellofemoral osteoarthritis and to identify prognostic outcome factors. Secondary aim is to investigate the influence of preoperative tibiofemoral osteoarthritis on the clinical outcome. From 2004 to 2010, 37 Avon patellofemoral prostheses were implanted in 32 patients. Clinical out...

OBJECTIVE To assess the inter- and intraobserver reproducibility of the original version and different descriptions of the Kellgren and Lawrence classification used in epidemiological studies for osteoarthritis of the knee. METHODS The study included 72 patients with osteoarthritis of the knee. Three medical members of the Brazilian Society of Knee Surgery were invited to evaluate the images....

OBJECTIVES To investigate which variables identify people at high risk of progression of osteoarthritis of the hip. DESIGN Population based cohort study. SETTING Ommoord district in Rotterdam, Netherlands. PARTICIPANTS 1904 men and women aged 55 years and older from the Rotterdam study were selected on the basis of the presence of osteoarthritic signs on radiography at baseline, as define...

OBJECTIVE To summarise and review articles addressing the quality (validity, reliability, applicability) of seven commonly used definitions of hip osteoarthritis (OA) for epidemiological studies in order to use it primarily as a classification criterion. METHODS Medline and Embase were searched and articles studying the validity, reliability, or applicability of the definitions of hip OA were...