We developed transgenic mice conditionally expressing the neutrophil chemoattracting chemokine KC and the beta-galactosidase gene in multiple tissues. In these transgenic mice, doxycycline treatment induced a strong up-regulation in the expression of KC in several tissues, including heart, liver, kidney, skin, and skeletal muscle. Expression of KC within these tissues led to a rapid and substan...

BACKGROUND/AIMS Tissue degradation in corneal thinning disorders, such as keratoconus (KC), involves the expression of inflammatory mediators. The purpose of this study was to determine the levels of proinflammatory cytokines and matrix metalloproteinase 9 (MMP-9) in tears from both eyes of unilateral keratoconus (KC) patients. METHODS Thirty patients diagnosed as having asymmetrical KC (30 K...

Rice brown spot (BS), caused by Bipolaris oryzae, is one of the major diseases of rice in Japan. Quantitative resistance has been observed in local cultivars (e.g., CH45), but no economically useful resistant variety has been bred. Using simple sequence repeat (SSR) polymorphic markers, we conducted quantitative trait locus (QTL) analysis of BS resistance in backcross inbred lines (BILs) from a...

PURPOSE To study spontaneous K-complex (KC) densities during slow-wave sleep. The secondary objective was to estimate intra-non-rapid eye movement (NREM) sleep differences in KC density. MATERIALS AND METHODS It is a retrospective study using EEG data included in polysomnographic records from the archive at the sleep research laboratory of the Centre for Physiotherapy and Rehabilitation Scien...

Although Kupffer cells (KCs) play an important role in the liver's immune response, their role in colon cancer metastasis to the liver is unclear. We here analyzed the relationship between KCs and tumor cells (TCs) in colon cancer metastasis to the liver. Fischer 344 (F344) rats were divided into control group (KC+ group) and KC elimination group (KC‑ group), in which KC elimination was induced...

BACKGROUND Kangaroo care (KC) has been widely using to improve the care of low birth weight infants. However, very little is known about cerebral hemodynamics responses in low birth weight infants during KC intervention. The objective of this study was to elucidate the response of cerebral hemodynamics during KC in low birth weight infants. METHODS Near infrared spectroscopy measured regional...

PURPOSE To determine the interaction between corneal topographic and tomographic parameters and dry eye syndrome (DES) in keratoconus (KC) patients. METHODS Seventy-seven eyes of 49 patients with KC (age 34.4 ± 11.6 years) were enrolled in this study. In these 77 eyes we recorded surface regularity index (SRI), surface asymmetry index (SAI) and Klyce/Maeda KC index (KCI) using the Topographic...

This study is carried out to estimate the potential evapotranspiration (PET) and crop coefficient (Kc) for Wheat, BL 3235 variety. A lysimeter is installed to estimate PET at the experimental farm of Agricultural Research Center of Bhairahawa, which is located in western part of Nepal. The Blaney-Criddle formula is used to estimate the Kc for wheat. The estimated values of PET and Kc for wheat ...

OBJECTIVE We evaluated the involvement of keratinocyte-derived chemokine (KC) in neointimal hyperplasia and endothelial repair after arterial injury. METHODS AND RESULTS Expression of KC was detected by immunohistochemistry in carotid arteries of apolipoprotein E-deficient (apoE-/-) mice not earlier than 2 weeks after wire-injury. Double immunofluorescence staining revealed a colocalization o...

Keratoconus (KC) is a complex thinning disease of the cornea that often requires transplantation. The underlying pathogenic molecular changes in this disease are poorly understood. Earlier studies reported oxidative stress, metabolic dysfunctions and accelerated death of stromal keratocytes in keratoconus (KC) patients. Utilizing mass spectrometry we found reduced stromal extracellular matrix (...