Nuclear factor-kappa B (NF-kappa B) is a ubiquitously expressed cellular factor regulated by the cytoplasmic factor inhibitor protein kappa B alpha (I kappa B alpha). Activation of NF-kappa B by cytokines, including tumor necrosis factor-alpha (TNF-alpha), requires the phosphorylation and degradation of I kappa B alpha. An anti-apoptotic role for NF-kappa B has recently been suggested. In the p...

Assuming GCH $\mathsf {GCH}$ , we show that generalized eventually narrow sequences on a strongly inaccessible cardinal κ are preserved under one step iteration of the Hechler forcing for adding dominating κ-real. Moreover, if is unfoldable, 2 = + $2^\kappa =\kappa ^+$ and λ regular such < $\kappa ^+ \lambda$ then there set generic extension in which s ( ) b c $\mathfrak {s}(\kappa \kappa \math...

AIM To investigate the activation of nuclear factor-kappa B (NF-kappa B) and its function in glucocorticoid-induced Leydig cell apoptosis. METHODS The Leydig cells were isolated from male Sprague-Dawley rats (90 days of age) and were incubated with corticosterone (CORT, glucocorticoid in rat) for 6 h, 12 h and 24 h, respectively. The P65 subunit of NF-kappa B (NF-kappa B/P65) in nuclei and th...