Cytotoxic effects of vitamin K3 were evaluated utilizing the P388/S, L1210, EAT, S-180 and a multidrug-resistant variant of the P388 leukemia cells (P388/ADR). Antitumorigenic potential of vitamin K3 was assessed by MTT and DNA and RNA biosynthesis inhibition assay. A dose-dependent inhibition of P388/S and P388/ADR cell survival and [3H]thymidine and [3H]uridine incorporation (as a function of...

PURPOSE To evaluate the dose effect of vitamin K3 on wound healing mechanisms. METHODS Conjunctival fibroblasts were incubated for 24 hours. An artificial wound was made and the cells were incubated with fresh medium plus doses of vitamin K3 to be tested. Wound repair was monitored at 0, 18, 24, and 48 hours. Proliferation was measured in actively dividing cells by [(3)H]thymidine uptake. Six...

S. Bauer and M. Furuta defined a stable cohomotopy refinement of the Seiberg-Witten invariants. In this paper, we prove a vanishing theorem of Bauer-Furuta invariants for 4-manifolds with smooth Z2-actions. As an application, we give a constraint on smooth Z2-actions on homotopy K3#K3, and construct a nonsmoothable locally linear Z2-action on K3#K3. We also construct a nonsmoothable locally lin...

A graph G is called (K3,K3)-co-critical if the edges of G can be coloured with two colours without getting a monochromatic triangle, but adding any new edge to the graph, this kind of ’good’ colouring is impossible. In this short note we construct (K3,K3)-co-critical graphs of maximal degree O(n3/4).

Nikulin has classified all finite abelian groups acting symplectically on a K3 surface and he has shown that the induced action on the K3 lattice U⊕E8(−1) depends only on the group but not on the K3 surface. For all the groups in the list of Nikulin we compute the invariant sublattice and its orthogonal complement by using some special elliptic K3 surfaces.

In this paper, we consider the metric packing problem for the commodity graph of disjoint two triangles K3 +K3, which is dual to the multiflow feasibility problem for the commodity graph K3 + K3. We prove Karzanov’s conjecture concerning quarter-integral packings by certain bipartite metrics.

We apply the method of algebraic deformation to N-tuple of algebraic K3 surfaces. When N=3, we show that the deformed triplet of algebraic K3 surfaces exhibits a deformed hyperkähler structure. The deformation moduli space of this family of noncommutatively deformed K3 surfaces turns out to be of dimension 57, which is three times of that of complex deformations of algebraic K3 surfaces.

We investigated the mechanism of antitumor activity of the water-soluble derivative of menadione, menadione sodium bisulfite (vitamin K3), versus murine leukemia L1210. Vitamin K3, in concentrations greater than 27 microM, caused time- and concentration-dependent depletion of the acid-soluble thiol (GSH) pool. Maximal GSH depletion to 15% of control occurred at 45 microM vitamin K3. Vitamin K3-...

introduction: the most important aims of root canal preparation are the removal of vital pulp tissue, remaining necrotic debris and infected dentin, eliminating the bulk of bacteria present in the root canal system. the aim of this study was to compare the cleaning efficacy of hand k-flexofiles and rotary race and k3 instruments in root canal preparation. materials and methods: a total of 60 si...