The present study examined the effects of two novel dopamine D3 receptor compounds, NGB 2904 [N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-9H-fluorene-2-carboxamide], an antagonist, and CJB 090 [N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-4-(pyridin-2-yl)benzamide], a partial agonist, in two models of cocaine abuse in rhesus monkeys. To establish a dose range and time course of effec...

Multi-drug resistant (MDR), pathogenic Gram-negative bacteria pose a serious health threat, and novel antibiotic targets must be identified to combat MDR infections. One promising target is the zinc-dependent metalloamidase UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC), which catalyzes the committed step of lipid A (endotoxin) biosynthesis. LpxC is an essential, single c...

Somatostatin (somatotropin release inhibiting factor; SRIF) has widespread functions as a modulator of neural activity as well as of endocrine and exocrine secretion. In the present paper, the binding characteristics of somatostatin receptors have been investigated in rat long bones using the stable analogue, 125I-SDZ 204-090, as a ligand. Binding studies revealed the presence of a single class...

average grade of 4.0 gram:; [%r tonne go1 I and 215 001) tonnes with an average grade of 2.0 gran s per tonne ill the 200 and 440 pit areas of the upper all :ration zone, respectively (Figure 2). Carmac Resources Lttl. (now Camnc r Resourwr Ltd.) optioned the Hank claims in 1990 and drilled : h e holes totalling 1 090 metres in the Upper and Lovnrzones, then terminated the option. Homestake Can...

X iv :p hy si cs /0 40 20 85 v3 [ ph ys ic s. da ta -a n] 1 1 M ar 2 00 4 FINDING TWO-DIMENSIONAL PEAKS Z. K. SILAGADZE Budker Institute of Nuclear Physics, 630 090, Novosibirsk, Russia Abstract. Two-dimensional generalization of the original peak finding algorithm suggested earlier is given. The ideology of the algorithm emerged from the well known quantum mechanical tunneling property which e...

1 Department of Mathematical Sciences, University of Durham, South Road, Durham DH1 3LE, United Kingdom [email protected] 2 Institut de Recherche Mathématique, Université de Rennes I and CNRS UMR 6625, 35042 Rennes Cedex, France [email protected] 3 Instituto de Matemática e Estatı́stica, Universidade de São Paulo, Rua do Matão 1010, CEP 05508-090, São Paulo SP, Brasil...

Luís G. Esteves 1, Rafael Izbicki 2, Julio M. Stern 1 and Rafael B. Stern 2,* 1 Institute of Mathematics and Statistics, University of São Paulo, São Paulo 13565-905, Brazil; [email protected] (L.G.E.); [email protected] (J.M.S.) 2 Department of Statistics, Federal University of São Carlos, São Carlos 05508-090, Brazil; [email protected] * Correspondence: [email protected]; Tel.: +55-16...

1Department of Health Sciences, University of Genoa, Via Antonio Pastore 1, 16132 Genoa, Italy 2Toxicology Institute, Preventive Medical College, Third Military Medical University, Chongqing 400038, China 3Department of Genetics and Evolutionary Biology, Institute of Bioscience, University of São Paulo, 05508-090 São Paulo, SP, Brazil 4Laboratory of Toxicology UT-BIORAD, ENEA, CR Casaccia, Via ...