BACKGROUND Dropout is a serious challenge to clinical trials in psychiatry, yet standard outcome analyses with mixed models do not account for dropout, while joint modeling uses dropout from a survival model to adjust the outcome from a mixed model, but is untested in clinical trials of schizophrenia. AIMS To compare mixed and joint modeling in three acute phase pivotal placebo controlled tri...

a generalized heckman model is used for the joint modeling of longitudinal continuousresponses and dropout in order to see the influence of a small perturbation of the elements of thecovariance structure on displacement of the likelihood. the perturbation from random dropout in thedirection of informative dropout is considered for mastitis data.

Empirical studies show that there is stronger dependency between large losses than large profit in financial market, which undermine the performance of using symmetric distribution for modeling these asymmetric. That is why the assuming normal joint distribution of returns is not suitable because of considering the linier dependence, and can be lead to inappropriate estimate of VaR. Copula theo...

background: the salvage proximal femoral osteotomy is performed in mild or moderate osteoarthritis when the articulating surfaces are normal and relieves the subject’s pain. because the importance of angular mal-alignment of the femur bone at the hip junction accurate pre-op planning based on patient specific anatomy is required to prevent any lower limb misalignment and joint problem pre-opera...

We compare the effect of joint modeling of phonological features to independent feature detectors in a Conditional Random Fields framework. Joint modeling of features is achieved by deriving phonological feature posteriors from the posterior probabilities of the phonemes. We find that joint modeling provides superior performance to the independent models on the TIMIT phone recognition task. We ...

Abstract Acyclic phase-type (PH) distributions have been a popular tool in survival analysis, thanks to their natural interpretation terms of aging toward its inevitable absorption. In this article, we consider an extension the bivariate setting for modeling joint lifetimes. contrast previous models literature that were based on separate estimation marginal behavior and dependence structure thr...