Introduction: Dark neurons which their morphological characteristics are consistent with those of cells undergoing apoptosis, are generated as an acute or delayed consequence of several pathological situations. The present study was designed to evaluate whether inflammatory pain regarding the role of NO and JNK lead to the formation of dark neurons in the dorsal horn of the lumbar spinal cor...

Neprilysin (NPL) is a wrinkle-inducing membrane bound elastase that expressed abundantly in UV-exposed and aged dermal fibroblasts (JBC2010). The overexpression of NPL essentially associated with enhanced epithelial-mesenchymal cytokine interactions (EMCI) mainly via IL-1α which has distinct potential to stimulate the expression by human (HDFs)(BJ2012). over-expression also accelerates wrinkle ...

Background/Aim: Non-small cell lung cancer patients with epidermal growth factor receptor (EGFR) mutation have been shown to a good response erlotinib, tyrosine kinase inhibitor of EGFR. In this study, we found that the death pathways activated by erlotinib in 2D and 3D culture systems are different. Materials Methods: The induced were evaluated flow cytometry immunoblotting both EGFR mutant ce...

Abstract Background Epidural fibrosis is one of the aetiologies pain following a spinal revision surgery. It reported that specific members mitogen – activated protein kinases (MAPK) family might mediate neuropathic pain. However, roles epidural caused by repeated surgeries and pain-related proteins in causing post surgery syndrome remain unknown. Using rat adhesion model, this study, we evalua...

ABSTRACT Regeneration after damage requires early signals to trigger the tissue repair machinery. Reactive oxygen species (ROS) act as that are sensed by MAP3 kinase Ask1, which in turn activates phosphorylation MAP kinases p38 and JNK. The sustained or high activation of these can result apoptosis, whereas short low promote regeneration. Using Ask1-dependent regeneration program, we demonstrat...

BACKGROUND Cervical cancer is the 2nd most frequently diagnosed gynecological cancer. Therefore, it clinically significant to discover an effective anti-cancer approach. OBJECTIVES This study aimed investigate effects of low-intensity ultrasound irradiation (USI) on cervical cells and associated mechanisms cell death. MATERIAL AND METHODS Normal human HaCaT lines C33A, Hela Siha were cultured γ...

Objective(s): Aberrant expression of CCL5 has been found in several kinds of inflammatory diseases, and the roles of CCL5 in these diseases have also been reported. However, the role of CCL5 in infantile pneumonia is still unclear. Thus, the function and acting mechanism of CCL5 in the in vitro model of infantile pneumonia were researched in this study. Materials and Methods: Human fetal lung f...

What does it do? JNK is important for sending signals from the cell membrane to nuclear transcription factors, increasing their ability to activate transcription. JNK signalling has been implicated in cell growth, oncogenic transformation, cell differentiation and cell death. Stimuli that activate JNK include growth factors, cytokines and just about any kind of stress (see Figure). JNK can be t...