BACKGROUND The cause of juvenile chronic arthritis (JCA) is unknown. Pauciarticular JCA is the most common subtype and can be subdivided into early (type I) and late onset (type II) forms, the latter clinically resembling reactive arthritis. METHODS The cellular immune responses to bacteria associated with reactive arthritis in blood and synovial fluid from 39 children with pauciarticular JCA...

OBJECTIVE To assess the psychological, behavioural and social adjustment of children (7-11 years) and adolescents (12-16 years) with juvenile chronic arthritis (JCA). Higher rates of maladjustment were expected to be found in these patients. METHODS Self report questionnaires were used within the context of personal interviews. Family functioning and social support were studied as well. Forty...

SIR, We read with interest the paper by Gilman and coworkers who showed that in rats with adjuvant-induced arthritis peritoneal macrophages produce higher amounts of interleukin 1 (IL-1), while splenic T cells produce less interleukin 2 (IL-2) than controls.' We found comparable results when studying interleukin production by peripheral blood mononuclear cells in children with juvenile chronic ...

We have shown previously that the putative prostate carcinoma cell lines TSU-Pr1 and JCA-1 share a common origin. The observation that these cell lines have p53 and Ha-ras mutations identical to those in bladder carcinoma cell line T24 prompted us to investigate their possible interrelations. We used cytogenetics and DNA profiling to compare the genetic backgrounds of the three cell lines. At l...

The Java Cryptography Architecture, JCA in short, was created to allow JCA-compliant cryptography providers to be plugged into a JCA-aware application at run time. This configurable feature makes JCA widely used and assures its success. However, the public key cryptographic service interfaces defined by JCA are based on the conventional public key cryptography, which is a single-sender-singlere...

OBJECTIVE To determine the expression of tumour necrosis factor alpha (TNF alpha) and its soluble receptors (p55 and p75) in the sera and synovial fluid of patients with juvenile chronic arthritis (JCA), and their correlation with disease activity parameters. METHODS Ninety eight sera from 45 patients with JCA (14 systemic, 12 polyarticular, 19 pauciarticular), 20 sera from age matched health...

OBJECTIVE To identify possible imbalance of tumour necrosis factor alpha (TNFalpha) and its soluble receptors in the different subgroups of juvenile chronic arthritis (JCA). METHODS Serum and synovial fluid samples from 45 children were examined, 25 pauciarticular JCA, 13 polyarticular JCA and seven spondyloarthropathy. TNFalpha, sTNFRI and sTNFRII levels were measured by EASIA and enzyme-lin...

Antibodies to nuclear antigens were assessed in 23 children with juvenile chronic arthritis (JCA) and 66 of their first degree relatives. Serum samples from 16 patients with JCA (70%) and nine relatives (14%) had antinuclear antibodies by indirect immunofluorescence. Antibodies against nuclear antigens in rabbit thymus extract or an erythroblastoid cell line (K562) were detected by countercurre...

Lathrolestesivoriensis sp. n. is described from Côte d'Ivoire. This is the second record of the genus from the Afrotropical region and the first record of the genus and the subfamily for the country. Illustrated re-description of Lathrolestesruwenzoricus (Benoit, 1955) is also provided.

Periprosthetic osteolysis (PO) is a frequent complication in patients with joint implants. There are no data regarding the prevalence of PO in patients with rheumatoid arthritis (RA), juvenile chronic arthritis (JCA), ankylosing spondylitis (AS), and osteoarthritis (OA). OBJECTIVES To evaluate the prevalence of PO in patients with RA, JCA, AS, and OA, who have undergone total hip replacement ...