Ivermectin (IVM) is a broad-spectrum anthelmintic drug used to treat human parasitic diseases like river blindness and lymphatic filariasis. By activating invertebrate pentameric glutamate-gated chloride channels (GluCl receptors; GluClRs), IVM induces sustained chloride influx and long-lasting membrane hyperpolarization that inhibit neural excitation in nematodes. Although IVM activates the C....

The elaboration of a quality oocyte is integrally linked to the correct developmental progression of cumulus cell phenotype. In humans and nonhuman primates, oocyte quality is diminished with in vitro maturation. To determine the changes in gene expression in rhesus monkey cumulus cells (CC) that occur during the final day prior to oocyte maturation and how these changes differ between in vitro...

The informative vector machine (IVM) is a practical method for Gaussian process regression and classification. The IVM produces a sparse approximation to a Gaussian process by combining assumed density filtering with a heuristic for choosing points based on minimizing posterior entropy. This paper extends IVM in several ways. First, we propose a novel noise model that allows the IVM to be appli...

OBJECTIVE To evaluate the maturation and post-thaw survival rates of immature oocytes to determine whether in vitro maturation (IVM) should be attempted prior to or after cryopreservation. DESIGN Nonrandomized observational study. SETTING Private academic and clinical reproductive center. PATIENT(S) Patients (n = 71) who donated immature unusable oocytes after vaginal oocyte retrieval (VO...

The developmental competence of in vitro-matured (IVM) rhesus macaque cumulus oocyte complexes (COCs) is deficient compared with in vivo-matured (IVM) oocytes. To improve oocyte quality and subsequent embryo development following IVM, culture conditions must be optimized. A series of experiments was undertaken to determine the role of epidermal growth factor (EGF) during IVM of rhesus macaque C...

Integrated Vector Management (IVM) is advocated by the World Health Organization (WHO) as the pivotal platform for vector control. The threat for malaria and emerging and re-emerging vector borne diseases is increasing. However, adoption and deployment of the IVM strategy has been minimal. Though malaria endemic countries are embracing and consolidating the IVM approach, real time entomological...

Zusammenfassung We evaluate the performance of Import Vector Machines (IVM), a sparse Kernel Logistic Regression approach, for the classification of hyperspectral data. The IVM classifier is applied on two different data sets, using different number of training samples. The performance of IVM to Support Vector Machines (SVM) is compared in terms of accuracy and sparsity. Moreover, the impact of...

Abstract Study question Can supplementation with neuregulin 1 during a pre-IVM culture step followed by sequential stimulation FSH and amphiregulin improve IVM outcomes? Summary answer Supplementation improves post-IVM bovine embryo production What is known already Evidence that gradual activation of the maturation cascade favours nuclear-cytoplasmic synchrony cumulus-oocyte communication has m...

Our objective was to determine if the resistance mechanism to moxidectin (MOX) is similar of that to ivermectin (IVM) and involves P-glycoproteins (PGPs). Several Caenorhabditis elegans strains were used: an IVM and MOX sensitive strain, 13 PGP deletion strains and the IVM-R strain which shows synthetic resistance to IVM (by creation of three point mutations in genes coding for α-subunits of gl...