Intravascular large B-cell lymphoma (IVLBCL) is a rare and deadly malignancy involving the growth of lymphoma cells within vessel lumina of all organ types. IVLBCL is further divided into the hemophagocytic Asian variant and a classical Western variant. Both variants are difficult to diagnose by imaging, and although diagnostic criteria have been developed to guide workup, histopathological exa...

Intravascular large B cell lymphoma (IVLBCL) is a rare type of extranodal diffused large B-cell lymphoma. IVLBCL with primary lung lesion is very rare and it is very difficult to diagnose. Radiographic findings of pulmonary IVLBCL are nonspecific and resembling interstitial lung diseases. Reversed halo sign (RHS) was initially reported in patients diagnosed with cryptogenic organizing pneumonia...

Intravascular large B-cell lymphoma (IVLBCL) is a rare form of non-Hodgkin’s that selectively involves the lumina vessels, and may present as ischemic stroke. A 62-year-old man presented with progressive aphasia, dementia, seizure stroke-like symptom. Brain magnetic resonance imaging revealed dynamic fluid attenuated inversion recovery lesions multiple punctate microbleeds in bilateral subcorti...

Intravascular large B-cell Lymphoma (IVLBCL) is a rare subtype of extranodal non-Hodgkin’s lymphoma that challenging to diagnose and has poor prognosis. Here, we describe two patients newly diagnosed with IVLBCL at our institution: an African man hemophagocytic-syndrome-associated Italian woman cutaneous variant IVLBCL. They presented very different clinical manifestations. Both cases were in t...

IVLBCL: intravascular large B-cell lymphoma I ntravascular large B-cell lymphoma (IVLBCL) is a very rare type of non-Hodgkin lymphoma in which tumor cells proliferate within the lumina of small blood vessels, particularly within capillaries, causing clinical symptoms. The clinical presentation of IVLBCL differs among geographic areas. For example, Asians more commonly present with fever, hepato...

Intravascular large B-cell lymphoma (IVLBCL) is a rare and aggressive subtype of systemic extranodal non-Hodgkin diffuse large B-cell lymphoma (DLBCL). We report a rare case of IVLBCL who showed diffuse 18F-fluorodeoxyglucose (FDG) uptake in the lung in FDG-positron emission tomography/computed tomography (PET/CT) without respiratory symptoms or chest CT abnormalities. Serum biochemical studies...

Myelofibrosis (MF) is often accompanied by chronic myeloid leukemia, hairy cell leukemia, or certain primary myeloproliferative neoplasms, but is rarely associated with lymphoid neoplasms. We herein describe a case of intravascular large B-cell lymphoma (IVLBCL) with MF. IVLBCL is a rare, aggressive type of extranodal B-cell lymphoma, defined by proliferation of lymphomatous cells within small-...

Intravascular large B cell lymphoma (IVLBCL) is a rare, aggressive extranodal B cell lymphoma, classified as a subset of diffuse B cell lymphoma. IVLBCL typically occurs in elderly persons and the clinical heterogeneity of the condition makes the diagnosis elusive in most cases. Most of the reported cases have been in the Asian population with the majority of the cases being diagnosed postmorte...

IVLBCL: Intravascular large B-cell lymphoma INTRODUCTION Intravascular large B-cell lymphoma (IVLBCL) is a rare disease with an incidence of less than 1 person per 1 million. It is a subtype of diffuse large B-cell lymphoma in which the lymphoma cells reside predominantly within the lumina of blood vessels (particularly capillaries) with circulating neoplastic cells detectable in the peripheral...

Intravascular large B-cell lymphoma (IVLBCL) is a very rare type of non-Hodgkin lymphoma, usually affecting elderly patients and characterized by selective infiltration of neoplastic cells within blood vessels' lumina. IVLBCL diagnosed with prostatic involvement is extremely rare. We report a patient of 65 years old, having mostly neurological complaints but diagnosed with IVLBCL upon histopath...