Introduction Hepatic drug metabolism by cytochrome P450 type 3A (CYP3A) is impaired in patients with acute kidney injury (AKI) [1]. The mechanisms underlying this are unclear. CYP2D6 is another clinically important hepatic CYP subtype, responsible for approximately 25% drug metabolism. Common phenotypic variation exists, the clinical relevance of which has not been previously demonstrated in th...

Özet Amaç: Tek başına veya birlikte sistemik olarak verilen tramadol ve gabapentinin farelerde akut ağrıda olası antinosiseptif etklerini araştırmaktır. Gereç ve Yöntem: Hayvan etik komitesinin onayı sonrası; 96 BALB/c albino dişi fare 12 gruba ayrıldı: (I) Enjeksiyon yapılmaksızın kontrol grubu, (II) salin uygulanan kontrol grubu, (III)-(IV) tramadol 10 mg/kg veya 30 mg/kg uygulanan gruplar, (...

BACKGROUND Intravenous patient-controlled analgesia (IV PCA) using opiods is an accepted method for delivering postoperative analgesia. The aim of this study was to compare fentanyl and tramadol with IV PCA after spinal anesthesia (SA) and general anesthesia (GA) following cesarean section (C/S). METHODS Ninety women were randomly assigned to three groups (n=30). Group 1 was treated with IV f...

background: laryngoscopy is an invasive technique that is associated with severe cardiovascular complications. this study was designed to compare the preventing effect of two doses tramadol injection on the heart rate and blood pressure changes after laryngoscopy and tracheal intubation in elective surgical patients. methods: in this clinical trial study, 189 elective surgical patients randomly...

To the editor: Postoperative pain management is important not only in patient wellbeing, but in recovery. An appropriate strategy for pain management is required in the perioperative period. We read with interest the article on the necessity of intravenous patient controlled analgesia (IV-PCA) in patients undergoing mini mally invasive colorectal surgeries [1]. The authors suggested that IV-PCA...

This study aimed to compare the pharmacokinetics of tramadol between young and middle-aged dogs. Tramadol (4 mg/kg) was administered intravenously (IV) to young and middle-aged dogs (2 and 8-10 years, respectively). Plasma concentrations of tramadol were measured using high-performance liquid chromatography (HPLC), and its pharmacokinetics best fit a two-compartment model. The volume of distrib...

Background:-Numerous attempts have been made in the past to attenuate haemodynamic responses occurring during laparoscopic cholecystectomy. The present study compared effect of three opioids namely TRAMADOL, Fentanyl and Nalbuphine obtundation cholecystectomy terms Heart rate, BP (SBP, DBP MAP) secondary aim was calculate duration analgesia sedation score. Materials And Methods:-This a randomis...

Background: Many techniques, including multimodal analgesia, have been used to manage postoperative pain after laparoscopic cholecystectomy (LC). Although the number of studies using intravenous ibuprofen (IV) is still limited, has shown a potential role in managing pain. The primary outcome this study evaluate and compare impact IV forms acetaminophen on 24-hour opioid consumption management p...

Objective: The present study was designed to highlight the toxic impact of tramadol on both biochemical and histopathological aspects in rats' liver, kidney and thyroid gland. Methods: The study was performed on fifty healthy adult male albino rats divided into five groups with ten rats each. (Four experimental and control groups). Five rats (negative control) were kept in a quite non stressful...

This randomized, double-blind, double-dummy, multicenter trial compared efficacy and safety of tramadol HCL 37.5 mg/paracetamol 325 mg combination tablet with tramadol HCL 50 mg capsule in the treatment of postoperative pain following ambulatory hand surgery with iv regional anesthesia. Patients received trial medication at admission, immediately after surgery, and every 6 hours after discharge...